The expression patterns of minor fibrillar collagens during development in zebrafish.

Gene Expression Patterns : GEP
Ming FangJulia Thom Oxford

Abstract

Minor fibrillar collagens are recognized as the organizers and nucleators during collagen fibrillogenesis but likely serve additional functions. The minor fibrillar collagens include collagens type V and XI. Mutations of collagens type V and XI can cause Ehlers-Danlos, Stickler's, and Marshall's syndromes in human. We have characterized the spatiotemporal expression patterns of Col11a1, Col11a2, Col5a1 as well as Col5a3 in zebrafish embryos by in situ hybridization. Col5a1 is expressed in developing somites, neural crest, the head mesenchyme, developing cranial cartilage, pharyngeal arches and vertebrae. Col5a3 is detected in the notochord, mesenchyme cells in the eyes and lens. Both Col11a1 and Col11a2 have similar expression patterns, including notochord, otic vesicle, and developing cranial cartilages. Zebrafish may therefore serve as a valuable vertebrate model system for the study of diseases associated with collagens type V and XI mutations.

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Citations

Aug 16, 2011·Matrix Biology : Journal of the International Society for Matrix Biology·Cristian Dan NeacsuAndreas Tagariello
Jan 3, 2015·Developmental Biology·Jason R Jessen
Dec 29, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Qi YaoXue Zhong Liu
Sep 3, 2020·Journal of Developmental Biology·Makenna J HardyJulia Thom Oxford
May 17, 2018·Frontiers in Cell and Developmental Biology·Maggie S MaternRonna Hertzano
Sep 27, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Elizabeth A LawrenceChrissy L Hammond
Sep 17, 2021·BMC Research Notes·Jonathon C ReeckJulia Thom Oxford

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