The expression profile and clinical application potential of hsa_circ_0000711 in colorectal cancer

Cancer Management and Research
Jinyun LiMeng Ye

Abstract

Circular RNAs, as a class of long-time-ignored non-coding RNA, have been revealed as multifunctional RNAs in recent years, especially in the cancer research. However, the mechanism of most circular RNAs and their clinical application values in human cancers remain unknown, including in colorectal cancer (CRC). In this study, we focused on the expression pattern and clinical values of hsa_circ_0000711 in CRC. The expression level of hsa_circ_0000711 in 101 paired CRC tissues and 3 CRC cell lines (HCT116, COLO205, and H-T29), as well as human normal colon epithelial cell line NCM460, were measured by quantitative real-time polymerase chain reaction. Our results revealed that the expression level of hsa_circ_0000711 was significantly downregulated in CRC tissues (P=9.35E-16) and CRC cell lines (P<0.01). In addition, the area under the receiver characteristic curves was 0.81. The sensitivity and specificity were 0.91 and 0.58, respectively. Meanwhile, our study showed that low expression of hsa_circ_0000711 could serve as an independent prediction biomarker associated with poor overall survival of CRC patients (hazard ratio =2.409; 95% CI: 1.276-4.547; P=0.004). All of these results indicated that hsa_circ_0000711 may play a crucia...Continue Reading

Citations

Nov 17, 2020·Frontiers in Molecular Biosciences·Anuva RajappaPiyush Khandelia
Feb 18, 2020·Pathology, Research and Practice·Kaixuan Zeng, Shukui Wang
Mar 10, 2021·Journal of Cellular and Molecular Medicine·Anthony LiXiufen Zheng
Apr 6, 2021·Frontiers in Cell and Developmental Biology·Thasni KaredathJoel A Malek
Jul 1, 2021·Oncology Letters·Mingying Zhang, Shubin Wang
Sep 19, 2021·Cancer Cell International·Mandana Ameli-MojaradMaziar Ashrafian Bonab

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BETA
PCR

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GraphPad Prism
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