The Expression Profile and Prognostic Significance of Metallothionein Genes in Colorectal Cancer

International Journal of Molecular Sciences
Kuo-Chen HungKuen-Haur Lee

Abstract

Colorectal cancer (CRC) is a heterogeneous disease resulting from the combined influence of many genetic factors. This complexity has caused the molecular characterization of CRC to remain uncharacterized, with a lack of clear gene markers associated with CRC and the prognosis of this disease. Thus, highly sensitive tumor markers for the detection of CRC are the most essential determinants of survival. In this study, we examined the simultaneous downregulation of the mRNA levels of six metallothionein (MT) genes in CRC cell lines and public CRC datasets for the first time. In addition, we detected downregulation of these six MT mRNAs' levels in 30 pairs of tumor (T) and adjacent non-tumor (N) CRC specimens. In order to understand the potential prognostic relevance of these six MT genes and CRC, we presented a four-gene signature to evaluate the prognosis of CRC patients. Further discovery suggested that the four-gene signature (MT1F, MT1G, MT1L, and MT1X) predicted survival better than any combination of two-, three-, four-, five-, or six-gene models. In conclusion, this study is the first to report that simultaneous downregulation of six MT mRNAs' levels in CRC patients, and their aberrant expression together, accurately predi...Continue Reading

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Citations

Jun 13, 2020·International Journal of Molecular Sciences·Alessandro PassardiPaola Ulivi
Nov 30, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Daniela GerovskaIker Badiola
Sep 22, 2020·Pathology, Research and Practice·Qichen LiuZhong Chen
Sep 29, 2021·Cellular Oncology (Dordrecht)·Jhih-Yun HoChia-Hsiung Cheng

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