Abstract
Head and neck squamous cell carcinoma (HNSC) ranks as the sixth most common malignancy. The identification of highly specific and sensitive prognostic markers and potential drug targets can contribute to enhanced patient prognosis and individualized treatments. Heat shock proteins (HSPs) act as molecular chaperones and play a crucial role in maintaining cell homeostasis. Recently, research has indicated that HSPs also act as "evil chaperones" in cancer development. In this study, we assessed the expression of HSPs in HNSC patients using the ONCOMINE, GEPIA, and UALCAN databases. Mutations of HSP genes were also analysed using the cBioPortal database. Additionally, the expression levels of HSPs were verified using the Human Protein Altas (THPA) database. We found that the expression levels of HSPH1, HSPD1, SERPINH1, HSPA4, and HSP90AA1 were significantly higher in tissues from HNSC patients compared with normal tissues. Moreover, HSPH1, HSPD1, SERPINH1, HSPA4 and HSP90AA1 expressions were linked to disease progression. Survival analysis with the GEPIA and OncoLnc databases indicated that upregulation of HSPH1, HSPD1, SERPINH1, HSPA4 and HSP90AA1 was related to poor overall survival (OS). This study suggests that the HSPH1, HSPD1...Continue Reading
References
Feb 16, 1989·Nature·M Y ChengA L Horwich
Jan 1, 1988·Annual Review of Genetics·S Lindquist, E A Craig
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·M V BlagosklonnyL Neckers
Apr 11, 1997·Gene·Y KanekoJ Fujita
Jun 22, 2000·Cancer·K L KingW Y Lui
Aug 16, 2000·The EMBO Journal·P PandeyS Kharbanda
Aug 30, 2002·Journal of Cancer Research and Clinical Oncology·N KapranosA G Papavassiliou
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
Feb 28, 2004·FEBS Letters·Kazuhisa GotohJun Fujita
Oct 29, 2005·BMC Cancer·Francesco CappelloGiovanni Zummo
Oct 13, 2009·Molecular Cell·J I-Ju LeuDonna L George
Oct 20, 2010·PloS One·Magdalena SkrzypczakJerzy Ostrowsk
Nov 17, 2010·Cancer Letters·Gaëtan JegoCarmen Garrido
Jan 7, 2011·Journal of Biomedical Science·Chung-Yin WuKou-Juey Wu
Oct 11, 2011·Biochimica Et Biophysica Acta·Wei LiFred Tsen
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Sep 10, 2013·The Journal of Urology·Dong ChenAlexander Buchner
Oct 22, 2013·International Journal of Oncology·Noriko YamamotoNaohiko Seki
Mar 4, 2014·Pharmacology & Therapeutics·Pierre-Simon BellayePhilippe Bonniaud
Sep 11, 2014·PloS One·Xiao-shan LiWei-sheng Luo
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Feb 15, 2016·Trends in Biochemical Sciences·Stuart K Calderwood, Jianlin Gong
Jun 3, 2016·CA: a Cancer Journal for Clinicians·Kimberly D MillerAhmedin Jemal
Aug 5, 2016·Journal of Human Genetics·Kazuto KamikawajiHiromasa Inoue
Apr 14, 2017·Nucleic Acids Research·Zefang TangZemin Zhang
Jul 22, 2017·Neoplasia : an International Journal for Oncology Research·Darshan S ChandrashekarSooryanarayana Varambally
Sep 16, 2017·International Journal of Molecular Sciences·Yueh-Chun LeeBing-Yen Wang
Sep 25, 2017·EBioMedicine·Yan FuYongzhang Luo
Dec 5, 2017·Cell·Sidharth V PuramBradley E Bernstein
Dec 17, 2017·Oncotarget·Jianbiao ZhouWee-Joo Chng
May 4, 2018·Oncoimmunology·Chia-Chi ChenTze-Sing Huang
May 17, 2018·Journal of Cellular Biochemistry·Kisho OnoKen-Ichi Kozaki
Jun 21, 2018·World Journal of Surgical Oncology·Ting LiHui Li
Sep 13, 2018·CA: a Cancer Journal for Clinicians·Freddie BrayAhmedin Jemal
Jun 22, 2019·Scientific Reports·Bor-Hwang KangPei-Feng Liu
Dec 6, 2019·Oncotarget·Andro KošecLovorka Grgurević
Citations
Feb 3, 2021·Cells·Graham Chakafana, Addmore Shonhai
Jul 6, 2021·Frontiers in Oncology·Baoling LiuXueyuan Heng
Jul 8, 2021·FEBS Open Bio·Mohsen AhmadiPegah Mousavi
Oct 30, 2021·Frontiers in Molecular Biosciences·Li-Rong YanQian Xu
Dec 2, 2021·Molecular Biology Reports·Heba H TarabayA F Abdel-Aziz