The expressions of IGF-1, BMP-2 and TGF-β1 in cartilage of condylar hyperplasia

Journal of Oral Rehabilitation
Q MengJ Li

Abstract

Condylar hyperplasia is a complex post-natal growth abnormality of the mandible and condyle, which leads to facial asymmetry. We investigated the distributions of insulin-like growth factors (IGF-1), bone morphogenetic protein-2 (BMP-2) and transforming growth factor-β1 (TGF-β1) in cartilage of condylar hyperplasia and revealed relationships between age and the cartilaginous thickness. Twenty patients with condylar hyperplasia were divided into four histopathological types. The cartilaginous thickness and age in different histological types were analysed, and the localizations of IGF-1, BMP-2 and TGF-β1 were detected by immunohistochemistry analysis. The cartilaginous thickness of condylar hyperplasia significantly increased. The cartilaginous thickness of type III was significantly thicker than type I and type II, Bivariate correlation revealed a significant correlations between age and the cartilaginous thickness (r = 0·68, P = 0·01). However, the expressions of IGF-1, BMP-2 and TGF-β1 were the strongest in type I. In almost all types of condylar hyperplasia, the presence of IGF-1 and BMP-2 was found mainly in the proliferative chondrocyte layer and the hypertrophic chondrocyte layer, and only a few in the calcified chondrocy...Continue Reading

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Citations

Aug 23, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Pieter G RaijmakersDirk B Tuinzing
Aug 5, 2014·Phytotherapy Research : PTR·Ji Young KimHocheol Kim
Jan 3, 2016·International Journal of Oral and Maxillofacial Surgery·B VásquezM Del Sol
Jun 18, 2014·Progress in Orthodontics·Derek A SandersRavindra Nanda
Jun 2, 2016·Case Reports in Dentistry·Rashmi BansalAbhinav Kishore
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May 21, 2015·Dental press journal of orthodontics·Shreya GuptaSandhya Jain
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Jul 22, 2020·International Journal of Oral and Maxillofacial Surgery·S EspinosaE A Cafferata
Nov 15, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Huilin GuoXing Long

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