The expressions of protooncogenes and CYP1A in lungs of rats exposed to sulfur dioxide and benzo(a)pyrene

Regulatory Toxicology and Pharmacology : RTP
Guohua Qin, Ziqiang Meng

Abstract

Sulfur dioxide (SO2) is a ubiquitous air pollutant, present in low concentrations in the urban air, and in higher concentrations in the working environment. Benzo(a)pyrene (B(a)P), a polycyclic aromatic hydrocarbon, is a ubiquitous environmental contaminant with diverse toxicological effects. To investigate the interactions between SO2 and B(a)P, male Wistar rats were exposed to intratracheally instilled with benzo(a)pyrene (B(a)P; 3 mg) or SO2 (20 ppm) inhalation alone or together. The mRNA of CYP1A1 and 1A2, c-fos, and c-jun and protein levels of c-fos and c-jun were analyzed in lungs using a real-time reverse transcription-polymerase chain reaction (real-time RT-PCR) assay and Western blot analysis, respectively. And 7-ethoxyresorufin O-deethylase (EROD) and methoxyresorufin O-demethylase (MROD) activities were detected. In lungs of rats exposed to SO2 alone, the gene transcription of CYP1A1 and 1A2, the EROD and MROD activities were decreased. Meanwhile, the mRNA and protein levels of c-jun and c-fos were increased significantly. Exposure to B(a)P alone induced CYP1A1, CYP1A2 mRNA levels, the protein levels of c-jun, and the EROD and MROD activities in lungs. However, exposure to B(a)P plus inhaled SO2 neither increased nor...Continue Reading

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Citations

Apr 2, 2013·Environmental Toxicology and Pharmacology·Xiefan FangKristine L Willett
Jun 26, 2007·Regulatory Toxicology and Pharmacology : RTP·Ruijin LiJingfang Xie
Oct 18, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Amit SharmaDevendra Parmar
Oct 13, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Kumar Saurabh, Devendra Parmar
Jun 20, 2015·Journal of Toxicology and Environmental Health. Part a·Marjory MoreauMichèle Bouchard
Jul 31, 2013·Toxicology Letters·Lata Kaphalia, William J Calhoun
Jan 13, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shikha SrivastavaDevendra Parmar
Dec 17, 2014·Journal of Toxicology and Environmental Health. Part a·Marjory MoreauMichèle Bouchard
Jan 27, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Guohua Qin, Ziqiang Meng
Oct 27, 2007·Archives of Environmental Contamination and Toxicology·Ruijin LiJingfang Xie
Aug 18, 2009·Inhalation Toxicology·Jingfang XieZiqiang Meng
Aug 3, 2010·European Journal of Pharmacology·Junling LiZiqiang Meng

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