The extended life span of Drosophila melanogaster eye-color (white and vermilion) mutants with impaired formation of kynurenine.

Journal of Neural Transmission
Gregory F Oxenkrug

Abstract

Animal and human studies suggest that aging is associated with increased formation of kynurenine (KYN) from tryptophan (TRY). The rate-limiting factors of TRY-KYN metabolism are transmembrane transport of TRY, and activity of enzyme, TRY 2,3-dioxygenase (TDO2). Eye-color mutants, white (w1118) (impaired TRY transport) and vermilion (v48a and v2) (deficient TDO activity), were compared with wild-type Oregon-R (Ore-R) strain of Drosophila melanogaster. Female 1-day-old adult flies maintained on a standard medium, and acclimatized to 12-h light:12-h dark cycle were collected, and then regularly transferred to fresh medium every 3-4 days. The number of dead flies was recorded at the time of transfer. Forty flies were studied in each experimental group. The life span of w1118 (mean = 45.5 days), and v48a (mean = 47.6 days) and v2 (mean = 43.8 days), were significantly longer than of wild-type Ore-R flies (27.1 days) (p < 0.001, Logrank test). There were no differences in life span between w1118 and v48a and v2 mutants. Present results suggest that prolongation of life span may be associated with slow rate of KYN formation from TRY.

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Citations

Apr 9, 2013·Trends in Molecular Medicine·Annemieke T van der Goot, Ellen A A Nollen
Jul 29, 2010·Expert Review of Neurotherapeutics·Hari Shanker Sharma, Aruna Sharma
Feb 24, 2015·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Hajime J Yuasa, Helen J Ball
Jun 4, 2011·Current Biology : CB·Susanna CampesanFlaviano Giorgini
Nov 5, 2014·Frontiers in Immunology·Merja Jaronen, Francisco J Quintana
Jan 28, 2017·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Vernon Beasley, Harold Dowse
Jul 17, 2010·Annals of the New York Academy of Sciences·Gregory F Oxenkrug
Feb 15, 2019·Nature Reviews. Drug Discovery·Michael PlattenChristiane A Opitz
Dec 28, 2018·Archives of Insect Biochemistry and Physiology·Colin S Brent, J Joe Hull
Nov 11, 2020·PLoS Genetics·Daniel C MaddisonFlaviano Giorgini
Dec 25, 2016·Insect Biochemistry and Molecular Biology·Simon C GroenNoah K Whiteman
Oct 9, 2020·Ageing Research Reviews·Andrey A ParkhitkoNorbert Perrimon
May 19, 2021·FEMS Microbiology Letters·Yuping YangXiaoyan Wang

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