The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort.

Journal of Public Health
Sebastián BlancoSandra Verónica Gallego

Abstract

To analyze the infectious extent of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in different settings where prevention strategies are critical to limit infection spread, we evaluated SARS-COV-2 viability to guide public health policies regarding isolation criteria and infection control. We attempted viral isolation in 82 nasopharyngeal swabs from 72 patients with confirmed SARS-COV-2 infection. Study population was divided into four groups: (i) Patients during the first week of symptoms; (ii) Patients with prolonged positive PCR; (iii) Healthcare workers from a hospital participating of an outbreak investigation, with SARS-COV-2 infection confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) and (iv) Recipients of convalescent immune plasma (CIP).Vero Cl76 cell-line (ATCC CRL-587) was used in assays for virus isolation. Plasma samples of CIP recipients were also tested with plaque-reduction neutralization test. We obtained infectious SARS-COV-2 isolates from 15/84 nasopharyngeal swabs. The virus could not be isolated from upper respiratory tract samples collected 10-day after onset of symptoms (AOS) in patients with mild-moderate disease. The knowledge of the extent of SARS-CoV-2 infectivity AOS...Continue Reading

References

Apr 3, 2020·Nature·Roman WölfelClemens Wendtner
Apr 29, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Bernard La ScolaDidier Raoult
May 23, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jared BullardGuillaume Poliquin
Jul 3, 2020·The Journal of Infection·Kieran A WalshPatricia Harrington
Aug 5, 2020·Emerging Infectious Diseases·Ranawaka A P M PereraMalik Peiris
Aug 15, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Anika SinganayagamRobin Gopal
Nov 29, 2020·The Journal of Infection·María Pilar Romero-GómezUNKNOWN SARS-CoV-2 Working Group
Feb 26, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Maria Dolores FolgueiraRafael Delgado

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