The extent of minimal residual disease reduction after the first 4-week imatinib therapy determines outcome of allogeneic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia

Cancer
Seok LeeChun-Choo Kim

Abstract

Previously, the authors demonstrated the positive impact of imatinib on the outcome of allogeneic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL). Here, the authors analyzed for risk factors that affect transplantation outcome, and they focused particularly on the prognostic relevance of minimal residual disease level at each treatment stage. Fifty-two patients with newly diagnosed Ph-positive ALL who completed allogeneic stem cell transplantation following imatinib therapy were enrolled in this study. For minimal residual disease monitoring, 548 marrow samples were analyzed by a real-time quantitative polymerase chain reaction assay. After the first 4-week imatinib therapy, 11 patients (21.2%) achieved molecular remission, and the remaining 41 patients had a reduction in BCR-ABL transcript levels (median, 3.21 log) from baseline value. The frequency of achieving a reduction in BCR-ABL transcript levels of at least 3 log at this stage was 36 (69.2%). Forty-eight (92.3%) of the 52 patients received stem cell transplantation during first complete remission. With a median follow-up of 49 months after stem cell transplantation, the 4-year relapse rate and dise...Continue Reading

References

Sep 20, 2002·Blood·Hervé DombretUNKNOWN Groupe d'Etude et de Traitement de la Leucémie Aiguë Lymphoblastique de l'Adulte (GET-LALA Group)
Dec 14, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Masamitsu YanadaUNKNOWN Japan Adult Leukemia Study Group
Aug 19, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Seok LeeChun-Choo Kim

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Citations

Aug 29, 2009·Current Opinion in Oncology·Ryan J Mattison, Richard A Larson
Aug 5, 2009·Current Opinion in Hematology·Tsila Zuckerman, Jacob M Rowe
Mar 13, 2014·Expert Review of Anticancer Therapy·Elena MainoRenato Bassan
Jul 27, 2011·Expert Review of Clinical Immunology·Aleksandra Petrovic, Gregory Hale
Jun 6, 2014·Cancer Investigation·Karim ArnaoutImad A Tabbara
Jan 17, 2016·British Journal of Haematology·Kirsten Bleckmann, Martin Schrappe
Jun 13, 2015·Blood·Dae-Young KimUNKNOWN Adult Acute Lymphoblastic Leukemia Working Party of the Korean Society of Hematology
Jul 8, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Renato BassanAlessandro Rambaldi
Dec 17, 2009·Hematology·Oliver G Ottmann, Heike Pfeifer
Oct 4, 2012·Blood·Monika BrüggemannMichael Kneba
May 28, 2020·Expert Review of Anticancer Therapy·Yu-Qian SunYing-Jun Chang
Jun 9, 2017·Korean journal of pediatrics·Jae Wook Lee, Bin Cho

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