PMID: 7524205Oct 15, 1994Paper

The extent of peritubular CD14 staining in renal allografts as an independent immunohistological marker for acute rejection

Transplantation
I M DooperM J Bogman

Abstract

Previously, we demonstrated that in acute interstitial rejection, immunohistological staining of renal allograft biopsies with the CD14 mAb WT14, reacting with human monocytes/macrophages, shows a characteristic peritubular increase of positive cells. To test the diagnostic value of this CD14 positivity, we compared, in 154 unselected renal allograft biopsies, the extent of peritubular WT14 staining with (a) the original histological diagnosis, made with knowledge of clinical data, (b) the retrospectively and blindly scored histological diagnosis according to the criteria of the Banff classification, and (c) the eventual clinical diagnosis, which included evaluation of the response to therapy. The extent of peritubular WT14 positivity, blindly scored on cryostat sections of the frozen part of the biopsies, correlated positively with the probability of acute rejection (AR). When using a cutoff of 70% WT14 positivity for the diagnosis of AR, as extracted from a receiver operating characteristic curve, the WT14 diagnosis had a positive predictive value of 91% and a negative predictive value of 56%, compared with the original histological diagnosis. Compared with the Banff diagnosis of AR (grade I-III), these values were 95% and 47...Continue Reading

Citations

Apr 12, 2000·Microbes and Infection·R LandmannW Zimmerli
Jan 12, 2000·Current Opinion in Nephrology and Hypertension·A Chandraker
Dec 10, 2013·Transplantation Proceedings·H KrichenT Ben Abdallah
Aug 21, 2014·Kidney International·Rafia S Al-Lamki, Tanya N Mayadas
Jul 31, 2009·Transplantation Reviews·Alex B Magil
May 7, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Markus HirschburgerVeronika Grau
Feb 7, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Kimberly A SinghAllan D Kirk
Mar 22, 2006·Transplantation Proceedings·A AktaşG Moray

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