The extracellular domain of Her2 in serum as a biomarker of breast cancer

Laboratory Investigation; a Journal of Technical Methods and Pathology
Alexandre PerrierMathieu Boissan

Abstract

Breast cancer is a major health problem worldwide. In ~15% of breast cancers, the epidermal growth factor receptor HER2, a transmembrane protein, is overexpressed. This HER2 overexpression is associated with an aggressive form of the disease and a poor clinical prognosis. The extracellular domain (ECD) of HER2 is released into the blood by a proteolytic mechanism known as "ECD shedding". This proteolytic shedding leaves a constitutively active truncated receptor in the membrane that is 10-100-fold more oncogenic than the full-length receptor and promotes the growth and survival of cancer cells. Shedding of the HER2 ECD is increased during metastasis: whereas 15% of primary breast cancer patients have elevated levels of serum HER2 ECD (sHER2 ECD), the levels reach 45% in patients with metastatic disease. Thus, sHER2 ECD has been proposed as a promising biomarker for cancer recurrence and for monitoring the disease status of patients overexpressing HER2. Nevertheless, in 2016, the American Society of Clinical Oncology advises clinicians not to use soluble HER2 levels to guide their choice of adjuvant therapy for patients with HER2-positive breast cancer, because the evidence was considered not strong enough. Currently, biomarkers...Continue Reading

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C ShihR A Weinberg
Jan 1, 1993·Breast Cancer Research and Treatment·T NaritaH Takagi
Jan 1, 1996·Breast Cancer Research and Treatment·P C WillsherJ F Robertson
Jan 1, 1997·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·R MolinaA M Ballesta
Mar 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L N HarrisR C Bentley
Nov 1, 2001·Annual Review of Cell and Developmental Biology·M D Sternlicht, Z Werb
May 7, 2002·Nature Reviews. Cancer·Mikala Egeblad, Zena Werb
Jun 6, 2002·Journal of the National Cancer Institute·Soonmyung PaikNorman Wolmark
Oct 21, 2005·The New England Journal of Medicine·Edward H RomondNorman Wolmark
Feb 8, 2006·Journal of Clinical Pathology·S-Y KongE S Lee
Jul 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edith A PerezRobert B Jenkins
Apr 19, 2007·Journal of the National Cancer Institute·Maurizio ScaltritiJosé Baselga
Jan 12, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V LudoviniL Crinò
May 3, 2008·Cancer Research·Marcel SmidJohn W M Martens
Feb 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Guido SauterMichael F Press
Feb 21, 2009·The New England Journal of Medicine·Christos Sotiriou, Lajos Pusztai
Feb 21, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael J DuffyPatricia M McGowan
Mar 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexandra F LearyMitch Dowsett
May 14, 2009·Journal of the National Cancer Institute·Maggie C U CheangTorsten O Nielsen
Sep 5, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Patricia Diana SørensenIvan Brandslund
Jul 14, 2010·Breast Cancer Research and Treatment·Isabell WitzelVolkmar Müller
Aug 3, 2010·The Breast : Official Journal of the European Society of Mastology·Mehdi FarzadniaNasrin Moheghi
May 10, 2011·Cancer Treatment Reviews·Chantal TséPierre-Jean Lamy
Jun 16, 2011·International Journal of Molecular Sciences·Hongtao ZhangXiaowei Xu
Apr 24, 2012·Biochimica Et Biophysica Acta·Lian LamHongtao Zhang
Oct 1, 2008·Indian Journal of Clinical Biochemistry : IJCB·Rani JamesP P Bapsy
Feb 14, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Ann Christina PedersenIvan Brandslund

❮ Previous
Next ❯

Citations

Aug 18, 2018·Journal of Cellular and Molecular Medicine·Sevinci PopCristiana Tanase
Oct 9, 2019·The Analyst·Tatsuro NakaoTakehiko Kitamori
Nov 6, 2018·Biosensors·Sandra Lara, André Perez-Potti
Jun 7, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Roopali RoyMarsha A Moses
Feb 5, 2021·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shi QuiHirotaka Iwase
Jan 28, 2021·Nature·Alfredo Quijano-RubioDavid Baker
May 11, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Diana LüftnerNadia Harbeck
Dec 11, 2019·Talanta·Maria FreitasCristina Delerue-Matos

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
ELISA
fluorescence microscopy
biopsy

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.