The Extracellular Matrix in Bronchopulmonary Dysplasia: Target and Source

Frontiers in Medicine
Ivana Mižíková, Rory E Morty

Abstract

Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth that contributes significantly to morbidity and mortality in neonatal intensive care units. BPD results from life-saving interventions, such as mechanical ventilation and oxygen supplementation used to manage preterm infants with acute respiratory failure, which may be complicated by pulmonary infection. The pathogenic pathways driving BPD are not well-delineated but include disturbances to the coordinated action of gene expression, cell-cell communication, physical forces, and cell interactions with the extracellular matrix (ECM), which together guide normal lung development. Efforts to further delineate these pathways have been assisted by the use of animal models of BPD, which rely on infection, injurious mechanical ventilation, or oxygen supplementation, where histopathological features of BPD can be mimicked. Notable among these are perturbations to ECM structures, namely, the organization of the elastin and collagen networks in the developing lung. Dysregulated collagen deposition and disturbed elastin fiber organization are pathological hallmarks of clinical and experimental BPD. Strides have been made in understanding the disturbances to ECM prod...Continue Reading

References

Jul 1, 1979·Toxicology and Applied Pharmacology·T H GardinerR C Reynolds
Nov 1, 1992·American Journal of Respiratory Cell and Molecular Biology·R A SinkinS Horowitz
Feb 1, 1992·American Journal of Respiratory Cell and Molecular Biology·L DamjanovichC A Buck
Sep 1, 1991·Pediatric Research·A Noguchi, T Nelson
Feb 11, 1991·The American Review of Respiratory Disease·L R MargrafB B Dahms
Oct 1, 1990·American Journal of Respiratory Cell and Molecular Biology·S E McGowan, R McNamer
Jul 1, 1989·American Journal of Respiratory Cell and Molecular Biology·D C Dean
Jul 1, 1989·Experimental Lung Research·A NoguchiR P Mecham
Oct 1, 1986·Developmental Biology·K KratochwilR Jaenisch
Apr 1, 1985·The American Review of Respiratory Disease·M C BruceA A Fanaroff
Jul 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·K BradleyR G Crystal
Feb 16, 1967·The New England Journal of Medicine·W H NorthwayD Y Porter
Dec 1, 1970·The Journal of Experimental Zoology·N K Wessells
Jan 1, 1970·Respiration; International Review of Thoracic Diseases·J L Emery
Jan 1, 1984·Annual Review of Medicine·D F Mosher
Jan 1, 1984·Differentiation; Research in Biological Diversity·T F Jaskoll, H C Slavkin
Nov 22, 1983·Biochimica Et Biophysica Acta·B MyersR B Rucker
Jan 1, 1982·The Journal of Clinical Investigation·S I Rennard, R G Crystal
Feb 5, 1981·Biochimica Et Biophysica Acta·M A DubickJ A Last
Nov 1, 1980·Toxicology Letters·V H SmithH A Ragan
Jul 1, 1980·The Anatomical Record·G Callas, V T Adkisson
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·L M CarlssonS L Marklund
Feb 1, 1994·Journal of Paediatrics and Child Health·M P Dyke, K D Forsyth
Jul 1, 1993·American Journal of Respiratory Cell and Molecular Biology·M G ArdenI Y Adamson
Feb 1, 1993·Developmental Biology·C B UnderhillM Culty
Mar 1, 1997·Experimental Lung Research·J Roman
Jul 1, 1997·American Journal of Respiratory Cell and Molecular Biology·S E McGowanL I Gold
Aug 1, 1997·Chemical & Pharmaceutical Bulletin·A RyuS Mashiko

❮ Previous
Next ❯

Citations

May 25, 2016·Molecular and Cellular Pediatrics·Claudio Nardiello, Rory E Morty
Nov 9, 2017·Molecular and Cellular Pediatrics·Prajakta Oak, Anne Hilgendorff
Jul 13, 2017·Physiological Genomics·Ivana MižíkováRory E Morty
Jan 10, 2017·Disease Models & Mechanisms·Claudio NardielloRory E Morty
Oct 5, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andrea PorzionatoMaurizio Muraca
Jul 4, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Heather MendenVenkatesh Sampath
Oct 4, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·David E Surate SolaligueRory E Morty
Aug 12, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Maryanne E Ardini-PoleskeUNKNOWN LungMAP Consortium
Mar 22, 2020·Scientific Reports·Sandrine GremlichTiziana P Cremona
Oct 10, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ettore LignelliRory E Morty
Oct 24, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kalsang DolmaCharitharth Vivek Lal
Jul 8, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Insa Bultmann-MellinAnja Sterner-Kock
Oct 8, 2020·Pediatric Research·Olachi J Mezu-Ndubuisi, Akhil Maheshwari
Dec 30, 2020·Histochemistry and Cell Biology·David Pérez-BravoRory E Morty
Dec 16, 2019·The American Journal of Pathology·Jared A MerenessThomas J Mariani
Mar 12, 2021·Nature Communications·Maria HurskainenBernard Thébaud
Jul 2, 2021·Matrix Biology Plus·Jared A Mereness, Thomas J Mariani
Jun 18, 2021·Frontiers in Medicine·Jennifer SucreAnne Hilgendorff
Dec 12, 2021·Molecular and Cellular Pediatrics·Mitali Sahni, Vineet Bhandari

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage
transgenic
light microscopy
electrophoresis
deamination
gene knockout

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.