The extracellular matrix in multiple sclerosis: an update

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
R A Sobel

Abstract

Extracellular matrix (ECM) molecules play important roles in the pathobiology of the major human central nervous system (CNS) inflammatory/demyelinating disease multiple sclerosis (MS). This mini-review highlights some recent work on CNS endothelial cell interactions with vascular basement membrane ECM as part of the cellular immune response, and roles for white matter ECM molecules in demyelination and remyelination in MS lesions. Recent basic and clinical investigations of MS emphasize axonal injury, not only in chronic MS plaques, but also in acute lesions; progressive axonal degeneration in normal-appearing white matter also may contribute to brain and spinal cord atrophy in MS patients. Remodeling of the interstitial white matter ECM molecules that affect axon regeneration, however, is incompletely characterized. Our ongoing immunohistochemical studies demonstrate enhanced ECM versican, a neurite and axon growth-inhibiting white matter ECM proteoglycan, and dermatan sulfate proteoglycans at the edges of inflammatory MS lesions. This suggests that enhanced proteoglycan deposition in the ECM and axonal growth inhibition may occur early and are involved in expansion of active lesions. Decreased ECM proteoglycans and their pha...Continue Reading

References

Mar 1, 1997·Brain : a Journal of Neurology·B FergusonV H Perry
Jan 29, 1998·The New England Journal of Medicine·B D TrappL Bö
Mar 14, 1998·Trends in Neurosciences·V W YongD R Edwards
May 26, 1998·Journal of Neuropathology and Experimental Neurology·R A Sobel
Aug 26, 1998·The American Journal of Pathology·R A SobelM Chen
Apr 9, 1999·Neuropathology and Applied Neurobiology·M R Del BigioC M Jacque
Jul 21, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M A Pires NetoR Lent
Jul 27, 1999·Neuropathology and Applied Neurobiology·N J GutowskiM L Cuzner
Sep 28, 1999·Current Opinion in Neurology·B D TrappR Rudick
Oct 12, 1999·Brain Pathology·B Kornek, H Lassmann
Jan 8, 2000·Journal of Neuroimmunology·F SellebjergP Garred
Jan 13, 2000·Neuropathology and Applied Neurobiology·P GanterM M Esiri
Jan 15, 2000·Advances in Experimental Medicine and Biology·H S Keirstead, W F Blakemore
Mar 8, 2000·Progress in Neurobiology·P Bovolenta, I Fernaud-Espinosa

❮ Previous
Next ❯

Citations

Jun 3, 2008·Cellular and Molecular Life Sciences : CMLS·A NairS D Miller
May 14, 2003·Journal of Neuroimmunology·Catharina M P VosHelga E de Vries
Apr 4, 2002·Biological Chemistry·Katerina Akassoglou, Sidney Strickland
Sep 29, 2006·Neurobiology of Disease·Jack van HorssenHelga E de Vries
Nov 10, 2013·Experimental Neurology·Danielle E Harlow, Wendy B Macklin
Aug 2, 2014·European Journal of Pharmacology·Shinji YamamotoKeisuke Yoshikawa
May 15, 2004·Progress in Neurobiology·John W Wright, Joseph W Harding
Jan 23, 2008·Multiple Sclerosis : Clinical and Laboratory Research·J VilisaarC S Constantinescu
May 3, 2018·Politics and the Life Sciences : the Journal of the Association for Politics and the Life Sciences·Michael C GrilloKeith B Lyle
Nov 6, 2014·Biomolecular Concepts·Tatsuhide Tanaka, Shigetaka Yoshida
Jan 5, 2002·Journal of Neuropathology and Experimental Neurology·R A Sobel, A S Ahmed
Jun 14, 2003·The Neurologist·Olaf StüveScott S Zamvil
Oct 19, 2020·The European Journal of Neuroscience·Harry PantazopoulosSabina Berretta
Mar 4, 2021·Reviews in the Neurosciences·Jia-Zhe LinWei-Jiang Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Journal of Neuropathology and Experimental Neurology
R A Sobel
Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
J Pieter de GijtKarel G H van der Wal
© 2021 Meta ULC. All rights reserved