The extracellular matrix molecule tenascin: expression in the developing chick retinotectal system and substrate properties for retinal ganglion cell neurites in vitro

The European Journal of Neuroscience
Susanne BartschU Bartsch

Abstract

To investigate the molecular mechanisms involved in the outgrowth of retinal ganglion cell axons in the tectum, the expression of the extracellular matrix molecule tenascin was analysed in the tectum and retina of chickens by immunocytochemistry and in situ hybridization. Tissue was analysed between embryonic days 4 and 12, just before and during the period when retinal ganglion cell axons innervate their target region, the optic tectum. In the tectum, tenascin immunoreactivity becomes detectable at the anterior pole at embryonic day 4, 2 days before retinal ganglion cell axons arrive, and spreads caudally with increasing age. At early stages, tenascin is predominantly accumulated in the stratum opticum, the zone of ingrowing retinal ganglion cell axons, and along their prospective pathway. In the stratum opticum, the molecule is associated with radial glial fibres, glial endfeet and retinal ganglion cell axons located in the immediate neighbourhood of radial glial fibres. At all ages investigated, tenascin mRNA is mainly restricted to cells located in the periventricular region, suggesting that the molecule is synthesized by radial glial cells. In the retina, tenascin is expressed by amacrine, displaced amacrine and horizontal...Continue Reading

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Citations

Dec 1, 1995·Journal of Neuroscience Research·N Mitrovic, M Schachner
Dec 28, 2012·Amino Acids·Igor JakovcevskiPavle R Andjus
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Nov 8, 2017·Frontiers in Integrative Neuroscience·Jacqueline ReinhardAndreas Faissner
Jun 8, 2021·Frontiers in Neuroscience·Susanne WiemannJacqueline Reinhard

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