The extracellular potential of a myelinated nerve fiber in an unbounded medium and in nerve cuff models

Biophysical Journal
Johannes J Struijk

Abstract

A model is presented for the calculation of single myelinated fiber action potentials in an unbounded homogeneous medium and in nerve cuff electrodes. The model consists of a fiber model, used to calculate the action currents at the nodes of Ranvier, and a cylindrically symmetrical volume conductor model in which the fiber's nodes are represented as point current sources. The extracellular action potentials were shown to remain unchanged if the fiber diameter and the volume conductor geometry are scaled by the same factor (principle of corresponding states), both in an unbounded homogeneous medium and in an inhomogeneous volume conductor. The influence of several cuff electrode parameters, among others, cuff length and cuff diameter, were studied, and the results were compared, where possible, with theoretical and experimental results as reported in the literature.

Citations

Sep 14, 2000·Medical & Biological Engineering & Computing·L N AndreasenS Lawrence
Oct 27, 2004·Medical & Biological Engineering & Computing·J TaylorJ Winter
Aug 29, 2006·Medical & Biological Engineering & Computing·Lotte N S Andreasen, Johannes J Struijk
Aug 13, 2008·Medical & Biological Engineering & Computing·N DonaldsonJ Taylor
Mar 1, 2012·Medical & Biological Engineering & Computing·John TaylorNick Donaldson
May 19, 2009·Anatomical Science International·Lotte N S Andreasen StruijkJohannes J Struijk
Mar 15, 2001·Journal of Neuroscience Methods·S Jezernik, W M Grill
Jan 11, 2002·Reviews in the Neurosciences·S J Mizumori, S Leutgeb
Aug 11, 2007·Medical Engineering & Physics·Iasonas F Triantis, Andreas Demosthenous
Jul 13, 2013·Neuromodulation : Journal of the International Neuromodulation Society·John L ParkerMichael J Cousins
Dec 23, 2014·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Fatemeh Karimi, Saeid R Seydnejad
Aug 29, 2013·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Thomas NielsenJohannes Struijk
Apr 25, 2014·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Robert RiegerSheng-Chih Chuang
Feb 9, 2005·Journal of Neuroscience Methods·Saso Jezernik
Feb 1, 2008·IEEE Transactions on Bio-medical Engineering·Lotte N S Andreasen StruijkJohannes J Struijk
Nov 16, 2010·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·José ZariffaMilos R Popovic
Mar 27, 2016·Medical & Biological Engineering & Computing·Olivier RosselGuy Cathébras
Sep 29, 2000·IEEE Transactions on Bio-medical Engineering·M RahalN Donaldson
Sep 23, 2000·IEEE Transactions on Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·J Perez-Orive, D M Durand
Jan 26, 2000·IEEE Transactions on Bio-medical Engineering·M RahalN Donaldson
Oct 8, 1999·IEEE Transactions on Bio-medical Engineering·S Jezernik, T Sinkjaer
Sep 7, 2002·IEEE Transactions on Bio-medical Engineering·Lotte N S Andreasen, Johannes J Struijk
Oct 17, 2003·IEEE Transactions on Bio-medical Engineering·Lotte N S Andreasen, Johannes J Struijk
Jul 28, 2001·Neurological Research·S JezernikT Sinkjaer
Oct 16, 2015·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Shaoyu QiaoKen Yoshida
Jan 1, 2017·Biomedical Physics & Engineering Express·L ChenB Feng
May 18, 2006·Journal of Neural Engineering·Anup RamachandranThomas Stieglitz
Jun 17, 2010·Journal of Neural Engineering·Saso JezernikManfred Morari
Aug 11, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·A Carpio
May 4, 2013·Journal of Neural Engineering·Martin SchuettlerJohn Taylor
Oct 4, 2019·Journal of Neural Engineering·Ryan G L KohJosé Zariffa
Aug 23, 2020·Nature Communications·Timothy M OtchyTimothy J Gardner
Nov 6, 2021·Journal of Neural Engineering·Calvin D EiberJames B Fallon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.