The extracellular proteases produced by Vibrio parahaemolyticus

World Journal of Microbiology & Biotechnology
George Osei-AdjeiYiquan Zhang

Abstract

Vibrio parahaemolyticus, a Gram-negative bacterium, inhabits marine and estuarine environments and it is a major pathogen responsible globally for most cases of seafood-associated gastroenteritis in humans and acute hepatopancreatic necrosis syndrome in shrimps. There has been a dramatic worldwide increase in V. parahaemolyticus infections over the last two decades. The pathogenicity of V. parahaemolyticus has been linked to the expression of different kinds of virulence factors including extracellular proteases, such as metalloproteases and serine proteases. V. parahaemolyticus expresses the metalloproteases; PrtV, VppC, VPM and the serine proteases; VPP1/Protease A, VpSP37, PrtA. Extracellular proteases have been identified as potential virulence factors which directly digest many kinds of host proteins or indirectly are involved in the processing of other toxic protein factors. This review summarizes findings on the metalloproteases and serine proteases produced by V. parahaemolyticus and their roles in infections. Identifying the role of V. parahaemolyticus virulence-associated extracellular proteases deepens our understanding of diseases caused by this bacterium.

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Citations

Nov 27, 2019·Journal of Fish Diseases·Leilei MaoQingpi Yan
Nov 17, 2020·Frontiers in Microbiology·San-Chi Chang, Chia-Yin Lee
Nov 26, 2021·Letters in Applied Microbiology·Yaqiu ZhangYoulu Su
Dec 3, 2021·Canadian Journal of Microbiology·Ya-Qiu ZhangYou-Lu Su

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Methods Mentioned

BETA
electrophoresis
environmental stress

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