The extracellular remodeling of free-soft-tissue autografts and allografts for reconstruction of the anterior cruciate ligament: a comparison study in a sheep model

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
Moritz DustmannSven U Scheffler

Abstract

Our study was aimed to advance the currently limited knowledge about differences in the biological remodeling of free soft-tissue tendon allografts and autografts for ACL reconstruction. Allogenic and autologous ACL reconstructions were performed in a sheep model using the flexor digitalis superficialis tendon. After 6, 12 and 52 weeks the animals were sacrificed. We analyzed the collagen crimp formation and its relationship to expression of contractile myofibroblasts in both graft types. Additionally, structural properties and ap-laxity were compared during biomechanical testing. At 6 weeks only descriptive differences were found between autografts and allografts with a more organized crimp pattern and myofibroblast distribution in autografts. Significant differences in myofibroblast density and crimp formation were found after 12 weeks. At these early stages, the progress of remodeling in autografts was more advanced toward the central areas than in allografts. At 1 year, grafts in both study groups returned to an ACL-similar structure. Structural properties and ap-laxity did not vary significantly between auto- and allografts at early healing stages. However, at 52 weeks, failure loads, stiffness and ap-drawer test showed su...Continue Reading

References

Aug 1, 1988·The Journal of Bone and Joint Surgery. British Volume·K ShinoK Ono
Nov 1, 1984·The Journal of Bone and Joint Surgery. British Volume·K ShinoK Ono
Mar 1, 1996·Clinical Orthopaedics and Related Research·C D HarnerM Silbey
Nov 1, 1995·The American Journal of Sports Medicine·K YasudaK Kaneda
Apr 1, 1996·The Journal of Bone and Joint Surgery. American Volume·F R Noyes, S D Barber-Westin
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·S K MasurS Petridou
Aug 1, 1996·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·D R StringhamR L Marcus
Aug 1, 1997·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·W R SheltonA D Dukes
Mar 12, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M M Murray, M Spector
Oct 20, 1999·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·P VorlatG Arnauw
Jan 12, 2001·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·R K PetersonA L Bomboy
May 17, 2001·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·K E WebsterK A Hameister
Feb 7, 2002·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Theodore I MalininWalid Mnaymneh
Mar 29, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Andreas WeilerNorbert P Haas
May 23, 2002·The American Journal of Sports Medicine·N Lindsay HarrisDonna L Wheeler
Sep 24, 2002·Der Unfallchirurg·F BonnaireT Lein
May 2, 2003·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Spencer K Y ChangAllen B Richardson
Mar 17, 2004·Archives of Orthopaedic and Trauma Surgery·Patrick HuntAndreas Weiler
Apr 2, 2004·Clinical Orthopaedics and Related Research·Pier Francesco IndelliDavid J Schurman
May 29, 2004·International Orthopaedics·T KustosTamás Bárdos
Jul 21, 2004·The American Journal of Sports Medicine·Andrew R CurranArnold D Scheller
Aug 18, 2004·The American Journal of Sports Medicine·Martha Meaney MurrayKurt P Spindler
Feb 11, 2005·The American Journal of Sports Medicine·Bernard R BachCharles A Bush-Joseph
Jul 14, 2005·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Gary G PoehlingBeth P Smith
Jul 14, 2005·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·David W ColeGary G Poehling
Oct 20, 2005·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·V B DuthonJ Ménétrey
Dec 13, 2006·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·C Thomas VangsnessMichael R Roberts
Apr 18, 2007·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Chadwick ProdromosKelvin Shi

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Citations

Jun 3, 2008·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·S U SchefflerA Weiler
Sep 16, 2008·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·J NylandD N M Caborn
Sep 1, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Markus WeissAndreas Weiler
Jun 21, 2012·Tissue Engineering. Part a·Colin Y L WoonJames Chang
Sep 13, 2013·Tissue Engineering. Part a·Yasuhiro OzasaChunfeng Zhao
Aug 17, 2012·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Tanja SchmidtAxel Pruss
Jun 16, 2012·Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology : SMARTT·Robert A MagnussenWilliam E Garrett
Jan 1, 2012·Journal of Long-term Effects of Medical Implants·Christopher R RowlandFarshid Guilak
Aug 29, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Rob P A Janssen, Sven U Scheffler
Jun 10, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Carola F van EckFreddie H Fu
Feb 5, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Rob P A JanssenSven U Scheffler
Jul 31, 2012·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Keith W LawhornHoward I Freedberg
Sep 2, 2008·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Braden C FlemingPaul D Fadale
Aug 14, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jin QuChunfeng Zhao
Jul 17, 2013·ANZ Journal of Surgery·Nicholas CalvertMark Hurworth
Mar 7, 2015·Clinical Orthopaedics and Related Research·Ata M KiapourMartha M Murray
Mar 1, 2015·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·E HerbstC Fink
Mar 19, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Braden C FlemingMartha M Murray
Nov 24, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michael LavagninoSteven P Arnoczky
May 26, 2017·Plastic and Reconstructive Surgery·Chao LongPaige M Fox
Jun 1, 2017·The Knee·Robert A MagnussenMichael V Knopp
May 6, 2015·The American Journal of Sports Medicine·Ata M KiapourMartha M Murray
Aug 16, 2016·Orthopaedic Journal of Sports Medicine·James E DarnleyRobert A Magnussen
May 10, 2018·The American Journal of Sports Medicine·Alexander E WeberAsheesh Bedi
Mar 27, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tao ZhangChunfeng Zhao
Nov 27, 2018·The American Journal of Sports Medicine·Emma L HeathLeo A Pinczewski
May 21, 2008·Clinical Orthopaedics and Related Research·Sven U SchefflerAxel Pruss

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