PMID: 5914253Sep 1, 1966

The extracellular space of the smooth muscle of the guinea-pig taenia coli

The Journal of Physiology
P J Goodford, E H Leach


1. The measured extracellular space of the taenia coli is large when small ions or molecules are used for the determination, and small when large molecules are used, even with identical experimental procedures.2. Extracellular hyaluronic acid has been detected histologically. It is apparently reduced by hyaluronidase.3. The extracellular inulin space increases after the tissue has been pretreated with hyaluronidase, although the ionic composition and wet weight are unchanged.4. It is suggested that the hyaluronic acid prevents the free entry of macromolecules such as inulin into the extracellular space by steric hindrance. Monatomic ions such as Na(+), Li(+), Cl(-), Ca(2+) therefore have a larger extracellular space available than is calculated on the basis of the inulin space.5. A slight shrinkage of the muscle cells can be detected when the incubation period is prolonged.


Jan 1, 1976·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·A C Parkin Bowler
Jan 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T NasuH Shibata
Jun 13, 1998·The Journal of Pharmacy and Pharmacology·T Nasu, M Sasaki
Jan 1, 1967·British Journal of Pharmacology and Chemotherapy·R E Handschumacher, J R Vane
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·T Nasu, N Suzuki
Apr 1, 1973·Analytica Chimica Acta·J H Ladenson, W C Purdy
Feb 24, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·T NasuH Shibata
Nov 30, 2000·Journal of Autonomic Pharmacology·T Nasu, M Nishikawa
Jan 1, 1972·Pflügers Archiv : European journal of physiology·S Bosteels, E Carmeliet
Jan 1, 1972·Pflügers Archiv : European journal of physiology·G EspositoV Capraro
Jan 1, 1970·Naunyn-Schmiedebergs Archiv Für Pharmakologie·J BartelsG Wille
Aug 1, 1983·The Journal of Pharmacy and Pharmacology·T NasuY Ishida
Apr 1, 1970·Archives internationales de physiologie et de biochimie·G Rorive

Related Concepts

Extracellular Space
Cavia porcellus
Large Intestine
Smooth Muscle

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