The extracellular vesicle of gut microbial Paenalcaligenes hominis is a risk factor for vagus nerve-mediated cognitive impairment.

Microbiome
Kyung-Eon LeeDong-Hyun Kim

Abstract

In a pilot study, we found that feces transplantation from elderly individuals to mice significantly caused cognitive impairment. Paenalcaligenes hominis and Escherichia coli are increasingly detected in the feces of elderly adults and aged mice. Therefore, we isolated Paenalcaligenes hominis and Escherichia coli from the feces of elderly individuals and aged mice and examined their effects on the occurrence of age-related degenerative cognitive impairment and colonic inflammation in mice. The transplantation of feces collected from elderly people and aged mice caused significantly more severe cognitive impairment in transplanted young mice than those from young adults and mice. Oral gavage of Paenalcaligenes hominis caused strong cognitive impairment and colitis in specific pathogen-free (SPF) and germ-free mice. Escherichia coli also induced cognitive impairment and colitis in SPF mice. Oral gavage of Paenalcaligenes hominis, its extracellular vesicles (EVs), and/or lipopolysaccharide caused cognitive impairment and colitis in mice. However, celiac vagotomy significantly inhibited the occurrence of cognitive impairment, but not colitis, in mice exposed to Paenalcaligenes hominis or its EVs, whereas its lipopolysaccharide or E...Continue Reading

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Citations

Dec 2, 2020·International Journal of Molecular Sciences·Sandor Haas-Neill, Paul Forsythe
May 1, 2021·International Journal of Molecular Sciences·Carlos M CuestaMaría Pascual
Apr 23, 2021·Neuroscience Research·Yunpeng Liu, Paul Forsythe
Sep 3, 2021·Journal of Physiology and Biochemistry·Ester Díez-SainzSilvia Lorente-Cebrián

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Datasets Mentioned

BETA
PRJNA598789

Methods Mentioned

BETA
ELISA
transmission electron microscopy
GAM
enzyme-linked immunosorbent assay
electrophoresis

Software Mentioned

Excel
GraphPad Prism
GraphPad
LEfSE
PICRUSt

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