The extraneuronal uptake and localization of noradrenaline in the cat spleen and the effect on this of some drugs, of cold and of denervation

The Journal of Physiology
J S GillespieJ A Hosie


1. Extraneuronal uptake of noradrenaline (NA) was examined in the cat spleen first by perfusing with NA for 10 min, followed by a 2-min wash to clear the extracellular fluid, then measuring the amount retained, its subcellular distribution and the tissue components involved as revealed by the development of the characteristic fluorescence. Secondly, thin spleen slices were exposed to NA in vitro and the development of fluorescence in various structures, particularly arterial smooth muscle, measured.2. The cat spleen accumulated large quantities of NA and this, like the development of fluorescence, was concentration-dependent. After particle separation most of the retained amine appeared in the high-speed supernatant, with a lesser amount in the coarse granule fraction. There was little amine in either the mitochondrial or microsomal fraction. The microsomal fraction from unperfused spleens was rich in NA, presumably from storage granules from the adrenergic nerves. On an intermittent sucrose density gradient the NA-rich particles sedimented between 1.0 and 1.5 M sucrose, corresponding to the recently described dense granules from bovine splenic nerves.3. Fluorescence histochemistry revealed several tissues accumulating NA. At a...Continue Reading


May 27, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·O Almgren, J Jonason
Apr 30, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·H BönischU Trendelenburg
Jun 27, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·H Bönisch
Feb 1, 1980·Clinical and Experimental Hypertension : CHE·N D VlachakisR F Maronde
Jun 1, 1981·Acta Physiologica Scandinavica·B Bengtsson
Jan 1, 1975·British Journal of Pharmacology·O D Gulati, N Sivaramakrishna
Oct 1, 1973·British Journal of Pharmacology·S R O'Donnell, N Saar
Mar 1, 1975·British Journal of Pharmacology·M E Jones, T L Spriggs
Oct 1, 1972·British Journal of Pharmacology·G BurnstockM E Wright
Sep 1, 1971·British Journal of Pharmacology·G BurnstockM Wright
Jan 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J Y ChangC Owman
Mar 27, 1974·Histochemistry·S A CrossJ R Vane
Feb 1, 1986·Perception & Psychophysics·E M ParkerK R Kluender
Mar 21, 2000·Perception & Psychophysics·S NittrouerM J Manhart
Feb 1, 1973·British Journal of Pharmacology·V A Alabaster, Y S Bakhle
Jul 1, 1973·The Journal of Pharmacy and Pharmacology·O Almgren, J Jonason
Apr 1, 1973·British Journal of Pharmacology·A G BlakeleyR J Summers
Mar 1, 1973·British Journal of Pharmacology·G Powis
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Apr 1, 1971·British Journal of Pharmacology·L L Iversen
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