PMID: 7022192Jul 1, 1981Paper

The extraordinary mutagenicity of nitropyrenes in bacteria

Mutation Research
R MermelsteinH S Rosenkranz

Abstract

Nitropyrenes cause frameshift mutations in Salmonella typhimurium. This activity which is restricted to frameshift mutations is unusual in several respects: (a) Nitropyrenes, as a class, are the most mutagenic chemicals reported in the literature; (b) The mutagenicity depends upon the formation of adducts between DNA and nitropyrene metabolites; (c) The penultimate intermediates responsible for mutagenic activity (hydroxylamines) are not obtained in all instances by reduction of the nitro function by the "classical" nitroreductase (the one that acts on nitrofurans and other simple nitrated polycyclic aromatic hydrocarbons) but by another nitroreductase which appears to be specific for higher nitrated polycyclic aromatic hydrocarbons; (d) The mutagenicity of nitropyrenes is enhanced when resting rather than growing bacterial cultures are used.

References

Jul 1, 1978·Cancer Letters·Y Y WangE T Wei
Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Jul 1, 1979·Mutation Research·A Goze, R Devoret
Aug 1, 1979·CRC Critical Reviews in Toxicology·T Sugimura, M Nagao
Feb 1, 1976·Mutation Research·M H Green, W J Muriel
Sep 16, 1975·Biochemical and Biophysical Research Communications·H S Rosenkranz, W T Speck
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B N AmesW E Durston
Jun 1, 1981·Mutation Research·E C McCoyR Mermelstein
Jan 1, 1980·Mutation Research·W T Speck, H S Rosenkranz
Apr 1, 1980·Mutation Research·C CheliH S Rosenkranz
Jan 1, 1981·International Journal of Environmental Analytical Chemistry·D SchuetzleT J Prater
Oct 1, 1980·Mutation Research·M J PeakS S Dornfeld

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Citations

Jan 1, 1991·Archives of Microbiology·M A HeitkampC E Cerniglia
May 1, 1983·Archives of Environmental Contamination and Toxicology·C R ClarkD E Seizinger
May 1, 1984·Chemico-biological Interactions·D W BryantB E McCarry
May 1, 1984·Mutation Research·G Klopman, H S Rosenkranz
Mar 1, 1982·Mutation Research·H S Rosenkranz
Feb 1, 1983·Mutation Research·E C McCoyR Mermelstein
Aug 1, 1985·Mutation Research·T SatoT Ishikawa
Aug 1, 1986·Mutation Research·M A McCartneyH S Rosenkranz
Jan 1, 1989·Mutation Research·B S Shane, A L Looney
Sep 1, 1994·Mutation Research·B NardiniE Clonfero
Jan 1, 1994·Mutation Research·Y KatohY Sano

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