The extrapulmonary dissemination of tuberculosis: A meta-analysis

International Journal of Mycobacteriology
Andrew Scott Webster, Wayne Xavier Shandera

Abstract

The epidemiology of the forty percent of tuberculosis patients who present with disseminated and/or extrapulmonary disease is in need of further study. Further study of such dissemination using published data from international indices may provide data which assist with control of tuberculosis. For each clinical or epidemiologic factor studied, summary odds ratios and corresponding 95% confidence intervals were calculated showing associations between such factors and documented extrapulmonary dissemination of tuberculosis. Eighteen studies fulfilled criteria for study of the clinical factors and nine for the cytokine studies. Significant factors associated with a greater risk of extrapulmonary dissemination were female gender (summary odds ratio, 1.92 (95% confidence intervals, 1.72-2.13), I-squared 86.9), age under 45 (1.37, 1.18-1.60, 63.7), and as well the absence of smoking, drinking and diabetes but not HIV infection (1.10, 0.91-1.32, 80.5). Among cytokines, the macrophage receptor protein P2X7 was associated most strongly associated with extrapulmonary dissemination of tuberculosis (2.28, 0.88-5.90, 92.9). Young age, female gender, and the macrophage purinergic receptor protein P2X7 were major factors associated with extr...Continue Reading

References

Jul 23, 2002·Journal of the American Geriatrics Society·Chi C LeungWai T Liu
Nov 1, 2002·Journal of Clinical Microbiology·Voahangy Rasolofo RazanamparanySuzanne Chanteau
Dec 18, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adrian OngCharles L Daley
Feb 26, 2004·The European Respiratory Journal·A C OgusO Yegin
Mar 23, 2005·The Journal of Infection·P R DonaldJ F Schoeman
Sep 20, 2005·Journal of Clinical Epidemiology·Johann CailholDidier Che
Apr 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jessie TorgersenWendy Cronin
Nov 11, 2006·American Journal of Respiratory and Critical Care Medicine·Suran L FernandoWarwick J Britton
Dec 13, 2006·Molecular Immunology·Christian SøborgPeter Garred
Sep 24, 2008·Seminars in Respiratory and Critical Care Medicine·Wafaa M El-Sadr, Simon J Tsiouris
Oct 2, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Heather M PetoLori R Armstrong
Mar 2, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·C A TaypeM-A Shaw
Mar 24, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Priya ShahPeter Ayliffe
May 17, 2011·Enfermedades infecciosas y microbiología clínica·José Francisco García-RodríguezPascual Sesma-Sánchez
May 26, 2011·Microbes and Infection·Walid Ben-SelmaJalel Boukadida
Aug 5, 2011·The American Journal of Tropical Medicine and Hygiene·Xinyu ZhangZhenhua Yang
Mar 6, 2013·Seminars in Respiratory and Critical Care Medicine·Philippe GlaziouMario Raviglione

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Citations

Jun 5, 2015·Frontiers in Cellular Neuroscience·Jonathan Paul SpanosMuazzam Jacobs
Mar 15, 2016·International Journal of Mycobacteriology·Wayne Xavier Shandera, Omar Merchant
Aug 28, 2018·The Cochrane Database of Systematic Reviews·Mikashmi KohliKaren R Steingart
Aug 31, 2020·International Journal of Mycobacteriology·Schehrazad Selmane, Mohamed L'Hadj
Mar 18, 2020·Global Health, Epidemiology and Genomics·Pavit TewatiaSanjeev Kumar
Jan 16, 2021·The Cochrane Database of Systematic Reviews·Mikashmi KohliKaren R Steingart
Jan 15, 2021·Microbiology and Molecular Biology Reviews : MMBR·Alexandra Y SoareTalia H Swartz
Feb 26, 2021·Gastroenterology Research and Practice·Shivantha AmarnathVivek Gumaste

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