PMID: 9428512Jan 15, 1998Paper

The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development

Cell
F PignoniS L Zipursky

Abstract

Sine oculis (so) and eyes absent (eya) are required for Drosophila eye development and are founding members of the mammalian Six and Eya gene families. These genes have been proposed to act with eyeless (Pax6) to regulate eye development in vertebrates and invertebrates. so encodes a highly diverged homeobox transcription factor and eya encodes a novel nuclear protein. We demonstrate that So and Eya (1) regulate common steps in eye development including cell proliferation, patterning, and neuronal development; (2) synergize in inducing ectopic eyes; and (3) interact in yeast and in vitro through evolutionarily conserved domains. We propose that an So/Eya complex regulates multiple steps in eye development and functions within the context of a network of genes to specify eye tissue identity.

References

Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S C FujitaS L Shotwell
Jan 1, 1995·Methods in Enzymology·P L Bartel, S Fields
Sep 16, 1996·FEBS Letters·K KawakamiT Saito
Jan 1, 1997·Trends in Genetics : TIG·M HammerschmidtA P McMahon
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·P X XuR L Maas

❮ Previous
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Citations

Dec 16, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V KalatzisC Petit
Jan 23, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·X CaubitS Krauss
Sep 25, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J E Treisman
Dec 2, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N M Bonini, M E Fortini
Jul 6, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K KawakamiK Ikeda
Sep 6, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N E Baker
Mar 29, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tanya T WhitfieldBryan Phillips
Jul 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·O LagutinG Oliver
Oct 31, 2001·Development Genes and Evolution·J P Kumar, K Moses
May 10, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Deneen M Wellik
Jul 19, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pin-Xian Xu
Oct 20, 2004·Journal of the Association for Research in Otolaryngology : JARO·Yuzhou ZhangRichard J H Smith
Mar 26, 2003·Developmental Biology·Madhuri Kango-SinghY Henry Sun
Jun 5, 2003·Developmental Biology·James J FabrizioStephen DiNardo
Aug 19, 2003·Developmental Biology·Magali SuzanneErnesto Sánchez-Herrero
Nov 7, 1998·Biochimica Et Biophysica Acta·H C SeoA Fjose
Aug 26, 1999·Trends in Genetics : TIG·W J Gehring, K Ikeo
Jun 1, 2002·Gene·Brian E FeeJohn L Cleveland
Feb 21, 2003·Current Opinion in Neurobiology·Timothy D Tayler, Paul A Garrity
Jun 6, 2000·Neuromuscular Disorders : NMD·G E Morris
Mar 1, 2003·Gene Expression Patterns : GEP·Simona CandianiZbynek Kozmik
Jun 24, 2009·Cell Research·Fani Papagiannouli, Bernard M Mechler
Jan 11, 2000·Eye·J W McAvoyF J Lovicu
Mar 10, 2006·Nature·Mathias F WernetClaude Desplan
Feb 24, 2009·Nature·Peter J CookMichael G Rosenfeld
Apr 2, 2004·Nature Reviews. Immunology·C Clare Blackburn, Nancy R Manley
Oct 21, 2000·Development, Growth & Differentiation·H Ogino, K Yasuda
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi SugaWalter J Gehring
Aug 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Takashi HiroseH Robert Horvitz
Jun 6, 2009·The Journal of Biological Chemistry·Aaron N PatrickHeide L Ford
Apr 11, 2000·Nucleic Acids Research·S E HarrisK J Johnson
Jun 11, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Debarshi MustafiKrzysztof Palczewski
Sep 17, 2002·Genes & Development·Jose BessaRichard S Mann
Mar 25, 1999·Genes & Development·F LoosliJ Wittbrodt
Jul 11, 2001·Genes & Development·C PunzoW J Gehring
Jun 7, 2002·Genes & Development·Deneen M WellikMario R Capecchi

❮ Previous
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