The ezrin metastatic phenotype is associated with the initiation of protein translation.

Neoplasia : an International Journal for Oncology Research
Joseph W BriggsChand Khanna

Abstract

We previously associated the cytoskeleton linker protein, Ezrin, with the metastatic phenotype of pediatric sarcomas, including osteosarcoma and rhabdomyosarcoma. These studies have suggested that Ezrin contributes to the survival of cancer cells after their arrival at secondary metastatic locations. To better understand this role in metastasis, we undertook two noncandidate analyses of Ezrin function including a microarray subtraction of high-and low-Ezrin-expressing cells and a proteomic approach to identify proteins that bound the N-terminus of Ezrin in tumor lysates. Functional analyses of these data led to a novel and unifying hypothesis that Ezrin contributes to the efficiency of metastasis through regulation of protein translation. In support of this hypothesis, we found Ezrin to be part of the ribonucleoprotein complex to facilitate the expression of complex messenger RNA in cells and to bind with poly A binding protein 1 (PABP1; PABPC1). The relevance of these findings was supported by our identification of Ezrin and components of the translational machinery in pseudopodia of highly metastatic cells during the process of cell invasion. Finally, two small molecule inhibitors recently shown to inhibit the Ezrin metastati...Continue Reading

Citations

Jul 8, 2015·Molecular and Cellular Biology·Haydar ÇelikAykut Üren
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Iwona LugowskaKatarzyna Szamotulska
Mar 27, 2015·Journal of Cellular Physiology·Marcella LaschiAnnalisa Santucci
May 4, 2016·The Journal of Biological Chemistry·Haydar ÇelikAykut Üren
Mar 25, 2014·Expert Review of Proteomics·Giulia BernardiniAnnalisa Santucci
Mar 30, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M LiS Q Fang
Oct 18, 2020·International Journal of Molecular Sciences·Anita K Luu, Alicia M Viloria-Petit
Jun 28, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James J MorrowChand Khanna

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