The ezrin-radixin-moesin family of proteins in the regulation of B-cell immune response

Critical Reviews in Immunology
Debasis Pore, Neetu Gupta

Abstract

Dynamic reorganization of the cortical cytoskeleton is essential for numerous cellular processes, including B- and T-cell activation and migration. The ezrin-radixin-moesin (ERM) family of proteins plays structural and regulatory roles in the rearrangement of plasma membrane flexibility and protrusions through its members' reversible interaction with cortical actin filaments and the plasma membrane. Recent studies demonstrated that ERM proteins not only are involved in cytoskeletal organization but also offer a platform for the transmission of signals in response to a variety of extracellular stimuli through their ability to cross-link transmembrane receptors with downstream signaling components. In this review, we summarize present knowledge relating to ERMs and recent progress made toward elucidating a novel role for them in the regulation of B-cell function in health and disease.

Citations

May 16, 2020·Frontiers in Bioengineering and Biotechnology·Mai IzumidaYoshinao Kubo
Jun 21, 2016·Immunological Reviews·Marine BretouAna-Maria Lennon-Duménil
Apr 27, 2019·Annual Review of Immunology·Michael R Gold, Michael G Reth
Mar 18, 2016·Journal of Biomedical Science·Godwin A Ponuwei
Nov 24, 2016·Journal of Cellular and Molecular Medicine·Orthodoxia NicolaouKyriacos Kyriacou
Sep 9, 2017·Scientific Reports·Caterina Di PietroEmanuela M Bruscia
Jul 14, 2016·The Journal of Allergy and Clinical Immunology·Chantal Lagresle-PeyrouIsabelle André-Schmutz
May 27, 2021·Organic Letters·Luca LizzadroDieter Schinzer
Jan 14, 2017·The American Journal of Pathology·Mark PinesOrna Halevy

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