The factor VIII protein and its function

Acta biochimica Polonica
Anna Mazurkiewicz-PisarekAndrzej Płucienniczak

Abstract

Factor VIII (FVIII), an essential blood coagulation protein, is a key component of the fluid phase blood coagulation system. Human factor VIII is a single chain of about 300 kDa consisting of domains described as A1-A2-B-A3-C1-C2. The protein undergoes processing prior to secretion into blood resulting in a heavy chain of 200 kDa (A1-A2-B) and a light chain of 80 kDa (A3-C1-C2) linked by metal ions. The role of factor VIII is to increase the catalytic efficiency of factor IXa in the activation of factor X. Variants of these factors lead frequently also to severe bleeding disorders.

Citations

Apr 7, 2020·Biochemical and Biophysical Research Communications·Zhang JunLi Xin
Mar 12, 2021·Cellular and Molecular Gastroenterology and Hepatology·Tirthadipa Pradhan-SunddMargaret V Ragni
Aug 28, 2021·Frontiers in Cell and Developmental Biology·Christopher StemGraça Almeida-Porada
Feb 20, 2020·Molecular Therapy. Methods & Clinical Development·Jenni FirrmanWeidong Xiao
Sep 24, 2021·The American Journal of the Medical Sciences·Nelson SeabrookThomas Abell
Nov 17, 2021·Expert Opinion on Biological Therapy·Steven W PipeOscar G Segurado

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