Dec 12, 2017

The Facultative Sex Coalescent with Crossing Over Recombination and Multi-Site Gene Conversion

BioRxiv : the Preprint Server for Biology
M HartfieldAneil F. Agrawal

Abstract

The extent of correlations between loci, as measured by linkage disequilibrium, is commonly used to infer the effect of different types of gene exchange. It can also provide information on rates of sex in facultative sexual organisms, as meiotic crossing over occurs during sexual reproduction. In addition, recent theoretical and empirical work has provided evidence that gene conversion shapes genetic diversity in facultative sexuals. Here we outline computational models of a facultative sexual coalescent process that includes both crossover recombination and multi-site gene conversion, to determine how linkage disequilibrium is affected with facultative sex. We demonstrate that the decay in linkage disequilibrium scales with the rate of sex if it is sufficiently high, indicating that linkage disequilibrium data can be potentially used to deduce rates of sex from genome data. With very low rates of sex, mitotic gene conversion both breaks down associations between alleles and removes within-individual diversity. The two combined effects produce complex linkage disequilibrium patterns. Furthermore, strong population structure and low rates of sex lead to lower average linkage disequilibrium values than those in panmictic populati...Continue Reading

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Mentioned in this Paper

Gene Polymorphism
Meiotic Cell Cycle
Reciprocal DNA Recombination
Patterns
Classification
Genome
Genes
Dysequilibrium Syndrome
Recombination, Genetic
Sexual Reproduction

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