The failure of anxiolytic therapies in early clinical trials: what needs to be done

Expert Opinion on Investigational Drugs
Adam Michael StewartAllan V Kalueff

Abstract

Anxiety spectrum disorders (ASDs) are highly prevalent psychiatric illnesses that affect millions of people worldwide. Strongly associated with stress, common ASDs include generalized anxiety disorder, panic, social anxiety, phobias and drug-abuse-related anxiety. In addition to ASDs, several other prevalent psychiatric illnesses represent trauma/stressor-related disorders, such as post-traumatic stress disorder and acute stress disorder. Anxiolytic drugs, commonly prescribed to treat ASDs and trauma/stressor-related disorders, form a highly heterogenous group, modulating multiple neurotransmitters and physiological mechanisms. However, overt individual differences in efficacy and the potential for serious side-effects (including addiction and drug interaction) indicate a need for further drug development. Yet, over the past 50 years, there has been relatively little progress in the development of novel anxiolytic medications, especially when promising candidate drugs often fail in early clinical trials. Herein, the authors present recommendations of the Task Force on Anxiolytic Drugs of the International Stress and Behavior Society on how to improve anxiolytic drug discovery. These recommendations cover a wide spectrum of aspe...Continue Reading

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Citations

Oct 20, 2015·Journal of Affective Disorders·Ashley L Greene, Nicholas R Eaton
Dec 20, 2016·História, ciências, saúde--Manguinhos·Francisco Ortega, Fernando Vidal
Mar 8, 2017·Psychopharmacology·Samantha R Spierling, Eric P Zorrilla
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May 16, 2021·Pharmacology, Biochemistry, and Behavior·Murilo S de AbreuAllan V Kalueff
Jun 15, 2021·Expert Opinion on Pharmacotherapy·Ansab Akhtar, Sangeeta Pilkhwal Sah

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