PMID: 11313139Apr 21, 2001Paper

The failure of different strains of Yersinia pestis to produce lipopolysaccharide O-antigen under different growth conditions is due to mutations in the O-antigen gene cluster

FEMS Microbiology Letters
J L PriorR W Titball

Abstract

The lipopolysaccharide (LPS) from eight strains of Yersinia pestis which had been cultured at 28 degrees C appeared to be devoid of an O-antigen when analysed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. LPS isolated from three of these strains which had been cultured at 37 degrees C also appeared to be devoid of an O-antigen. When the LPS from Y. pestis strain CO92 was purified and analysed by matrix-assisted laser desorption-ionisation time-of-flight mass spectrometry, the observed signals were in the mass range predicted for molecules containing lipid A plus the core oligosaccharide but lacking an O-antigen. The nucleotide sequence of Y. pestis strain CO92 revealed the presence of a putative O-antigen gene cluster. However, frame-shift mutations in the ddhB, gmd, fcl and ushA genes are likely to prevent expression of the O-antigen thus explaining the loss of phenotype.

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Citations

Dec 1, 2009·Expert Review of Vaccines·Valentina A Feodorova, Michael J Corbel
Feb 3, 2005·FEMS Microbiology Letters·Jingfu QiuRuifu Yang
Aug 3, 2005·FEMS Microbiology Letters·Dongsheng ZhouRuifu Yang
Apr 2, 2005·Antonie van Leeuwenhoek·Petra C F Oyston, Karen E Isherwood
Nov 21, 2007·Canadian Journal of Microbiology·Xiaoyi WangRuifu Yang
May 11, 2017·MBio·Kelsey A GreggRobert K Ernst
Sep 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Courtney E ChandlerRobert K Ernst
Oct 15, 2011·BMC Systems Biology·Pep CharusantiBernhard O Palsson
Mar 18, 2009·Infection and Immunity·Dongsheng Zhou, Ruifu Yang
Mar 22, 2005·Microbes and Infection·Yanping HanRuifu Yang

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