PMID: 6103629Mar 1, 1980Paper

The failure of L-prolyl-L-leucylglycinamide to inhibit the release of alpha-melanocyte-stimulating hormone in the rat

Acta Endocrinologica
A J ThodyF J Tilders

Abstract

We have studied the effect of L-prolyl-L-leucyglycinamide (PLG) on the release of melanocyte-stimulating hormone (MSH) from the rat pituitary gland both in vitro and in vivo. Superfusion of neurointermediate lobes with medium containing PLG or PLG-acetate (dose range 1-1000 ng/ml) did not affect the spontaneous release of MSH as determined by radioimmunoassay or by bioassay. Also during static incubations of rat hemipituitaries, PLG (6.6-50 ng/ml) was without effect on alpha-MSH release. Administration of PLG (1-250 ng iv) to intact male and female rats and rats being lesions in the medio-basal hypothalamus did not induce a fall in serum alpha-MSH levels. It is concluded that PLG does not affect the release of alpha-MSH from the rat intermediate lobe. It is unlikely therefore that PLG mediates the inhibitory influence of the CNS on MSH release.

Citations

Oct 14, 1983·European Journal of Pharmacology·J P BurbachD De Wied
Feb 1, 1991·Pharmacology, Biochemistry, and Behavior·B B GorzalkaS A Tanco
May 1, 1982·Peptides·T L O'Donohue, D M Dorsa
Jan 1, 1982·Neurochemistry International·M E CelisC Fisher
Jan 1, 1982·Journal of Neurochemistry·D de WildtA Witter

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