The false negative rate in cervical cytology. Comparison of monolayers to conventional smears

Acta Cytologica
E SprengerE A Knesel

Abstract

To compare cervical monolayers prepared by a density gradient technique to conventional smears. The study evaluated 2,863 patient samples. After conventional smears were prepared, the residual samples (collected in preservative fluid) were processed by the monolayer preparation system, which disaggregates the cells, removes nonclinical debris and layers the diagnostic material onto a microscopic slide. Slides were screened in Germany and the United States in masked studies. In the U.S. study, the false negative rate for the conventional smears was 9.4% when endocervical components were present and 16.7% when absent. The false negative rate for the monolayer preparation was 4.0% when endocervical components were present and 5.7% when absent. A comparison of the diagnostic results showed that the monolayer made possible the detection of 48 cases of low grade disease or higher that were not found on the conventional smear. The German study was independent but used the same samples. The results, although based upon the Papanicolaou classification, were similar. Cervical samples that are preserved in a liquid suspension and prepared using the density gradient monolayer technology have many advantages over conventional cervical cytol...Continue Reading

Citations

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