PMID: 11921323Mar 29, 2002Paper

The familywise error rate of a simultaneous confidence band for the incremental net health benefit

Health Economics
M MeisnerJ Wanderling

Abstract

Interest in the use of net health benefit in cost-effectiveness analysis derives from its optimality property for decision-making. A description of the results of an economic evaluation of health care interventions is incomplete if it does not include point and interval estimates of this outcome measure. A simultaneous confidence band for the incremental net health benefit, INHB(lambda), for all lambda may be obtained by forming a confidence interval based on student's t statistic, and letting the willingness-to-pay value, lambda, run over all values. The familywise error rate (FWER) of the simultaneous confidence band is the probability that the confidence interval does not cover the true INHB(lambda) for some value of lambda. We show that the FWER equals P(T(2)>t(2)), where T(2) follows Hotelling's central distribution and that the simultaneous confidence band does not cover the true INHB(lambda) if and only if a T(2) based confidence ellipsoid does not cover the true mean c-e vector.

References

May 1, 1997·Health Economics·E M LaskaC Siegel
May 5, 1998·Medical Decision Making : an International Journal of the Society for Medical Decision Making·A A Stinnett, J Mullahy
Jun 22, 2000·Health Economics·D F Heitjan
Apr 17, 2001·Statistics in Medicine·E M LaskaJ Wanderling
Jun 8, 2001·Statistics in Medicine·A R Willan, D Y Lin

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Citations

Apr 6, 2018·Journal of the Royal Society, Interface·Travers ChingCasey S Greene

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