The Fasting Hyperglycaemia Study: I. Subject identification and recruitment for a non-insulin-dependent diabetes prevention trial

Metabolism: Clinical and Experimental
M S HammersleyR Holman

Abstract

Subjects at increased risk for developing non-insulin-dependent diabetes mellitus (NIDDM) were encouraged via a public awareness campaign, general practitioners, or a direct approach (in the case of women with previous gestational diabetes) to attend one of three English and two French centers for fasting plasma glucose (FPG) measurement. Of 1,580 subjects (mean +/- SD age, 47 +/- 10 years), 29% were male, 56% had a diabetic relative, 20% had a history of elevated blood glucose or glycosuria, and 9% previously had gestational diabetes. Thirty-one percent (493) had an initial increased fasting glucose ([IFG] 5.5 to 7.7 mmol.L-1), 3% (41) a diabetic fasting glucose ([DFG] > or = 7.8 mmol.L-1), and 66% (1,046) a normal fasting glucose ([NFG] < 5.5 mmol.L-1). Four hundred forty-one of the 493 returned for a second FPG measurement, and 67% (293) of these had a similar value on repeat testing 2 weeks later. A 75-g, 2-hour oral glucose tolerance test (OGTT) in 223 of these subjects showed that 37% (83) had impaired glucose tolerance (IGT), 26% (58) diabetes mellitus (DM), and 37% (82) normal glucose tolerance (NGT). Seven percent of self-referred patients had NIDDM by World Health Organization (WHO) criteria. Eighty-eight percent of t...Continue Reading

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Citations

Feb 19, 2003·Diabetes Research and Clinical Practice·R W SimpsonP Z Zimmet
Apr 12, 2002·Controlled Clinical Trials·Richard R RubinUNKNOWN DPP Research Group
Mar 31, 2004·Journal of Clinical Pharmacology·L Michael Prisant
Feb 25, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·S E ManleyJ M Smith
Oct 5, 2019·Clinical Trials : Journal of the Society for Clinical Trials·Karen BrackenGary Wittert
Nov 25, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·A J FarmerP M Salkovskis

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