Abstract
Self-referred subjects (N = 227) thought to be at increased risk of developing diabetes who had fasting plasma glucose (FPG) values in the range of 5.5 to 7.7 mmol.L-1 on two consecutive occasions 2 weeks apart were randomized to sulfonylurea therapy (gliclazide, < or = 160 mg.d-1) or to a control group allocated either to double-blind placebo or to no tablets. Subjects were randomly allocated also to reinforced or basic healthy-living advice in a factorial design. A total of 201 subjects have been evaluated for 1 year in three English and two French hospital outpatient centers. Those allocated to sulfonylurea had a significant (P < .001) reduction in median FPG compared with the control group (6.0 mmol.L-1 to 5.6 mmol.L-1, P < .001, v 6.0 mmol.L-1 to 6.0 mmol.L-1, NS). Median hemoglobin A1c (HbA1c) also improved (P < .0002; 5.8% to 5.6%, P < .001, v 5.7% to 5.6%, NS), as did mean beta-cell function (62% to 70%, P < .01, v 62% to 61%, NS). Mean body weight was unchanged in subjects allocated to sulfonylurea (81.7 kg to 82.4 kg, NS), but decreased in the control group (81.6 kg to 80.4 kg, P < .01). More subjects in the sulfonylurea group versus the control group reported one or more minor symptoms of hypoglycemia over 1 year (50...Continue Reading
Citations
Mar 10, 2006·Diabetologia·N G ForouhiUNKNOWN EDEG
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Asbjørn Hróbjartsson, Peter C Gøtzsche
Jun 28, 2014·Diabetes Care·Lalitha GudipatyMichael R Rickels
May 24, 2001·The New England Journal of Medicine·A Hróbjartsson, P C Gøtzsche
Mar 21, 2007·BMC Medicine·Karin MeissnerUlla Mitzdorf
Mar 17, 2010·The New England Journal of Medicine·Rury R HolmanRobert M Califf
Aug 17, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Erik Snorre ØfjordTrond Jenssen
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Bianca HemmingsenBernd Richter
Mar 31, 2004·Journal of Clinical Pharmacology·L Michael Prisant
Mar 25, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·O J PhungC I Coleman
Dec 6, 2017·The Cochrane Database of Systematic Reviews·Bianca HemmingsenBernd Richter
Jul 1, 2012·Expert Review of Endocrinology & Metabolism·Markolf Hanefeld
Nov 13, 2008·Diabetologia·A L GloynR R Holman
Oct 19, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·M IncaniM G Baroni
Jul 28, 2021·Trials·Sigurlaug H HafliðadóttirRobin Christensen
Dec 28, 2010·Primary Care Diabetes·Barbara WesterhausGuillermo E Umpierrez