The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes

International Journal of Obesity : Journal of the International Association for the Study of Obesity
I DahlmanPeter Arner

Abstract

Obese subjects have increased number of enlarged fat cells that are reduced in size but not in number in post-obesity. We performed DNA methylation profiling in fat cells with the aim of identifying differentially methylated DNA sites (DMS) linked to adipose hyperplasia (many small fat cells) in post-obesity. Genome-wide DNA methylation was analyzed in abdominal subcutaneous fat cells from 16 women examined 2 years after gastric bypass surgery at a post-obese state (body mass index (BMI) 26±2 kg m(-2), mean±s.d.) and from 14 never-obese women (BMI 25±2 kg m(-2)). Gene expression was analyzed in subcutaneous adipose tissue from nine women in each group. In a secondary analysis, we examined DNA methylation and expression of adipogenesis genes in 15 and 11 obese women, respectively. The average degree of DNA methylation of all analyzed CpG sites was lower in fat cells from post-obese as compared with never-obese women (P=0.014). A total of 8504 CpG sites were differentially methylated in fat cells from post-obese versus never-obese women (false discovery rate 1%). DMS were under-represented in CpG islands and surrounding shores. The 8504 DMS mapped to 3717 unique genes; these genes were over-represented in cell differentiation pat...Continue Reading

References

Jan 10, 2002·Genes & Development·Adrian Bird
Dec 24, 2004·The New England Journal of Medicine·Lars SjöströmUNKNOWN Swedish Obese Subjects Study Scientific Group
Jun 28, 2005·Nucleic Acids Research·Bing ZhangJay Snoddy
Jul 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mario F FragaManel Esteller
Feb 2, 2006·Genome Research·Marina BibikovaJian-Bing Fan
Mar 22, 2007·Journal of Lipid Research·Jaswinder K Sethi, Antonio J Vidal-Puig
May 6, 2008·Nature·Kirsty L SpaldingPeter Arner
May 10, 2008·Bioinformatics·Pan DuSimon M Lin
Jun 3, 2009·Nature Reviews. Endocrinology·Peter D GluckmanAlan S Beedle
Oct 14, 2009·PloS One·Olivier MassonEmmanuelle Liaudet-Coopman
Oct 23, 2009·Diabetes·Erik ArnerPeter Arner
Jun 10, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M KováčikováV Štich
Mar 13, 2012·Cell Metabolism·Romain BarrèsJuleen R Zierath
Apr 14, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Ruth J F Loos
May 24, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Melina M Musri, Marcelina Párrizas
May 30, 2012·Nature Reviews. Genetics·Peter A Jones
Jul 10, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Maryline OlivierWilfried Le Goff
Oct 12, 2012·Cellular and Molecular Life Sciences : CMLS·Jin Sun JungSoo Kyung Kang
Oct 17, 2013·European Journal of Human Genetics : EJHG·Martine Doco-FenzyDavid Geneviève
Mar 19, 2014·Lancet·Katherine J DickNilesh J Samani
May 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Gabriel LachanceStephen Lee
May 16, 2014·Molecular Endocrinology·Dennis J Chia

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Citations

Feb 19, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Yen-Tsung HuangKarl T Kelsey
Jun 18, 2016·Nature Reviews. Endocrinology·Romain Barrès, Juleen R Zierath
Aug 2, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·A B CrujeirasJ M Fernandez-Real
Aug 10, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Anna Hernández-AguileraJorge Joven
Aug 19, 2016·Diabetologia·Peter ArnerIngrid Dahlman
Oct 6, 2016·Frontiers in Genetics·Otto K-W Cheung, Alfred S-L Cheng
May 18, 2016·Scientific Reports·Carmen de la RochaGertrud Lund
Sep 5, 2017·International Journal of Molecular Sciences·Lise M HardyWilfried Le Goff
Aug 12, 2018·Journal of Lipid Research·Aaron P FrankDeborah J Clegg
Dec 24, 2019·Annals of the New York Academy of Sciences·John R BrachtDeborah J Clegg
Aug 31, 2017·Current Atherosclerosis Reports·Sonsoles MorcilloFrancisco J Tinahones
Mar 3, 2017·Diabetology & Metabolic Syndrome·Priscila SalaDaniel Giannella-Neto
May 27, 2017·BMC Genomics·Ilhem MessaoudiOleg Varlamov
Jan 26, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Mohamed M AliAbeer M Mahmoud
Dec 24, 2019·Cell Metabolism·Paul PetrusMikael Rydén
Nov 17, 2020·Frontiers in Genetics·Shaza AsifKyoung-Han Kim
Nov 21, 2017·The Journal of Nutritional Biochemistry·Zhiyong ChengFabio A Almeida
Jun 16, 2021·Molecular Nutrition & Food Research·Yangmian YuanLing Zheng
Jul 9, 2021·Nature Reviews. Endocrinology·Elisabet Stener-Victorin, Qiaolin Deng
Aug 28, 2021·Biomedicines·Rosanna Capparelli, Domenico Iannelli

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