The fate of 14C-carbendazim in rat

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
J Krechniak, B Kłosowska

Abstract

The disappearance of 14C-carbendazim in rat (i.v. 12 mg/kg) followed the kinetics of a two-compartment open-system model. Half-lives of the alpha-phase were 0.1 h (blood), 0.16 h (liver), 0.25 h (kidney), and of the beta-phase: 2.15 h, 6.15 h, respectively. Two metabolites: methyl 5-hydroxy-2-benzimidazolecarbamate (5-HBC) and 2-aminobenzimidazole (2-AB) were formed very rapidly. Their peak concentrations in liver and kidney were 15 min after i.v. injection. Unchanged carbendazim was found in highest concentrations in blood. 5-HBC prevails in organs. 2-AB was present only in minor amounts. The extent of bioavailability in orally administered 14C-carbendazim (12 mg/kg) was about 85%. The disposition of radioactivity in subcellular fractions was not uniform, its highest concentration was in cytosol, the lowest in microsomes. The elimination of 14C-carbendazim in urine is biphasic. Half-lives of the alpha-phase were 1.4 h (i.v.) and 2.5 h (oral), and of the beta-phase 11.2 h and 12.1 h, respectively. Irrespective of the route of administration, 95% of the radioactivity in urine was composed of 5-HBC. The concentration of unchanged carbendazim in blood and of 5-HBC in urine may be of diagnostic value in acute poisoning with carbend...Continue Reading

References

Jun 1, 1973·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P G Douch
May 1, 1974·Journal of Agricultural and Food Chemistry·J A GardinerH Sherman
Jul 1, 1966·Toxicology and Applied Pharmacology·D J ToccoH J Robinson

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Citations

Feb 28, 2002·Journal of Pharmaceutical and Biomedical Analysis·Lee JiaSteve D Weitman
Mar 19, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Amina FaragEzzat Kadous
Aug 24, 1999·The Journal of Veterinary Medical Science·Y GotohT Nasu

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