PMID: 11342972May 9, 2001Paper

The fate of bacillus Calmette-Guerin after intravesical instillation

The Journal of Urology
C DurekA Bohle

Abstract

Long-term activation of immunocompetent cells of the bladder wall as well as case reports of systemic infections some months or years after intravesical bacillus Calmette-Guerin (BCG) therapy imply that mycobacteria may persist in the body. Therefore. we investigated the fate of BCG in patients after uncomplicated intravesical instillation therapy. A total of 49 patients were included in the study, from whom various numbers of specimens were used for mycobacterial culture and molecular biological detection techniques. In 23 patients who received a total of 128 instillations urine, sputum, venous blood and bladder biopsies were screened for BCG by acid-fast staining and culture at different times before and after instillation. From 16 of the 23 patients and from an additional 26 a total of 180 bladder biopsies obtained at intervals 3 to 30 months after instillation were screened for mycobacterial 16S ribosomal DNA by a nested polymerase chain reaction protocol. No viable BCG was found in venous blood or in 127 of 128 sputum specimens before and 2 hours after instillation. Two of 56 bladder biopsies were culture positive. In urine BCG was detected in 96.4% of the specimens after 2 hours and in 67.9% after 24 hours after instillat...Continue Reading

Citations

Jun 8, 2012·Science Translational Medicine·Claire BiotMatthew L Albert
May 11, 2011·Immunotherapy·Pierre L TriozziErnest Borden
Dec 15, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sandra M Arend, Dick van Soolingen
Feb 18, 2015·Clinical Journal of Oncology Nursing·Mary Weinstein Dunn
Aug 7, 2003·Expert Review of Vaccines·José A ChabalgoityRichard J Aspinall
Feb 28, 2006·International Journal of Surgical Pathology·Vanesa BijolHelmut G Rennke
Nov 14, 2018·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Marco MoschiniUNKNOWN European Association of Urology - European Society of Resident Urologists (EAU-ESRU)
Apr 24, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·H-Y Sun, N Singh
Mar 28, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Hiroshi HaradaMasaki Togashi
Nov 23, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Emilie Stavnsbjerg LarsenIsik Somuncu Johansen

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