The fate of dendritic cells in a mouse model of liver ischemia/reperfusion injury

Transplantation Proceedings
P LoiV Flamand

Abstract

Ischemia/reperfusion during liver transplantation triggers a complex cascade of inflammatory events that may lead to organ dysfunction. Herein, we investigated the consequences of hepatic ischemia/reperfusion on liver dendritic cells. Liver damage was documented by increased levels of serum alanine aminotransferase and by histopathology showing large areas of hepatocyte cytolysis. MHC class II+ CD45-B220 F4/80 dendritic cells were detected in necrotic areas 20 hours after reperfusion. Dendritic cells freshly isolated from reperfused livers displayed a mature phenotype characterized by upregulated expression of B7 costimulatory molecules; MHC-class II, and CD1d molecules. As shown by real-time PCR, IL-10, and TGF-beta mRNA accumulated in liver dendritic cells isolated after reperfusion, whereas IL-12p40 mRNA levels were decreased and IFN-gamma mRNA levels were unchanged. These results suggest that hepatic ischemia/reperfusion results in maturation of dendritic cells, which preferentially produce inhibitory cytokines.

References

Dec 1, 1985·Transplantation·S L AtallaJ P Cederna
Apr 1, 1994·European Journal of Immunology·F WillemsM Goldman
Oct 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O Le MoineJ Devière
Nov 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N HisamaM Ogawa
Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A B LentschM J Edwards
Mar 19, 1999·Immunology Today·A W Thomson, L Lu
Jul 27, 2001·The Journal of Surgical Research·B MosherE Crockett
Jul 28, 2001·European Journal of Gastroenterology & Hepatology·G Ramadori, T Armbrust
Jan 14, 2003·Gut·A H Lau, A W Thomson

❮ Previous
Next ❯

Citations

Mar 7, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Satoshi KubokiCharles C Caldwell
Jan 23, 2010·The Journal of Clinical Investigation·Zubin M BamboatRonald P DeMatteo
Apr 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Myung-Gyu KimSang-Kyung Jo
Aug 13, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Myung-Gyu KimHyoung-Kyu Kim
May 5, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Èlia RipollImmaculada Herrero-Fresneda
Jun 23, 2007·Transplant Immunology·Peter BorosJonathan S Bromberg
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P Boros, J S Bromberg
Nov 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tina L SumpterAngus W Thomson
Dec 12, 2012·Journal of Gastroenterology and Hepatology·Rowan F van GolenMichal Heger
Mar 6, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gary W NaceAllan Tsung
Oct 19, 2007·Cellular Immunology·Yanfei HuangKarl L Womer
Dec 24, 2010·World Journal of Cardiology·Yi Zhang, Cuihua Zhang
Oct 26, 2010·Nature Reviews. Immunology·Angus W Thomson, Percy A Knolle
May 13, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Justin D EllettKenneth D Chavin
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sei-ichiro TsuchihashiJerzy W Kupiec-Weglinski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Gastrointestinal and Liver Physiology
Satoshi KubokiCharles C Caldwell
Journal of Leukocyte Biology
Min-Fu Tsan, Baochong Gao
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Melissa J Burne-TaneyHamid Rabb
© 2022 Meta ULC. All rights reserved