PMID: 39107Sep 19, 1979

The fate of fetal and adult B-cell progenitors grafted into immunodeficient CBA/N mice

The Journal of Experimental Medicine
C J PaigeG Lee

Abstract

The relative ability of various precursors to generate functional B cells in vivo was assessed by transferring normal, chromosomally-marked CBA/H-T6T6 cells to irradiated or unirradiated immunodeficient CBA/N mice. Emergence of donor-derived B cells was monitored by means of a B-cell cloning assay (in which CBA/N cells are inactive), and by karyotpic analysis of lymphoid, myeloid, and stem cell metaphases. Grafts of lymph node, spleen, anti-mu surface immunoglobin suppressed bone marrow, sIg+ cell-depleted marrow, normal marrow, fetal liver, and yolk sac suggest: (a) there is little self-renewal of sIg+ B cells in these models; (b) pre-committed cells have extensive proliferative/differentiative potential and at least initially contribute most of the newly-formed B cells; (c) populations or pre-B cells obtained from various sources differ in their regenerative ability; (d) CBA/N mice are deficient in a category of pre-B cells which are found in fetal liver; and (e) selective B-cell chimerism results from grafting of unirradiated CBA/N mice.

References

Jan 1, 1992·International Journal of Cell Cloning·K Dorshkind, K S Landreth
Apr 1, 1981·Journal of Clinical Immunology·M D Cooper
Jan 1, 1982·Journal of Immunological Methods·C J Paige, H Skarvall
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·G M LewisJ H Slack
Jan 1, 1984·Developmental and Comparative Immunology·K S Landreth, P W Kincade
Jan 1, 1984·Developmental and Comparative Immunology·E S MedlockP W Kincade
Jun 1, 1995·Seminars in Immunology·I GodinA Cumano
Dec 1, 1984·Immunobiology·R H GislerG Holländer
Nov 26, 2002·Immunological Reviews·Jun HiroseP W Kincade
Feb 24, 2007·Nature Reviews. Immunology·K Dorshkind, Encarnacion Montecino-Rodriguez
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J I KurlandO N Witte
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J C WeillJ R Pink
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J E BarkerE C McFarland-Starr
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·U ChenU Staerz
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A CumanoC J Paige
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R Palacios, B A Imhof
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·I GodinA Cumano
Oct 1, 1984·The Journal of Experimental Medicine·K A DenisO N Witte
Jun 1, 1985·The Journal of Experimental Medicine·K HayakawaL A Herzenberg
Jun 1, 1985·The Journal of Experimental Medicine·Y Ron, J Sprent
Aug 1, 1987·The Journal of Experimental Medicine·K A DenisO N Witte
Sep 1, 1987·The Journal of Experimental Medicine·A de la HeraC Martinez
Dec 1, 1987·The Journal of Experimental Medicine·J N SiegelD I Cohen
Dec 1, 1992·The Journal of Experimental Medicine·P de VriesJ D Watson
Aug 2, 2005·Molecular and Cellular Biology·Maki Kobayashi-OsakiMasayuki Yamamoto
Dec 10, 2008·Blood·John E Dick
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·M C YoderP Mukherjee
Mar 1, 1987·International Reviews of Immunology·P W KincadeG Lee
Jan 1, 1982·Annals of the New York Academy of Sciences·P W KincadeG Lee
Mar 1, 1984·International Journal of Cell Cloning·W Chu-tse, L Min-pei
Jan 1, 1980·Scandinavian Journal of Immunology·J S CowderyA D Steinberg
Jan 1, 1982·Immunological Reviews·P W KincadeG Lee
Jan 1, 1979·Immunological Reviews·P Ralph
Jan 1, 1996·Immunity·S Delassus, A Cumano
Jan 1, 1981·Developmental and Comparative Immunology·O Lassila
Jan 1, 1981·Immunology Today·J W Schrader
Nov 1, 1981·Immunology Today·N R KlinmanJ M Teale

Citations

Oct 1, 1978·Cellular Immunology·P W KincadeC J Paige
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·F MelchersR A Phillips
Feb 1, 1977·The Journal of Experimental Medicine·P W Kincade
Mar 1, 1978·The Journal of Experimental Medicine·D VolfI Scher
Apr 1, 1978·Developmental and Comparative Immunology·T A Andrew, J J Owen
Dec 1, 1975·The Journal of Experimental Medicine·D MetcalfG A Gutman
Jul 1, 1976·European Journal of Immunology·J J OwenM D Cooper
May 1, 1976·Journal of Cellular Physiology·D MetcalfJ Stocker
May 1, 1976·The Journal of Experimental Medicine·P W KincadeM A Moore
Jun 1, 1972·The Journal of Experimental Medicine·L LafleurR A Phillips
Apr 1, 1973·The Journal of Experimental Medicine·L LafleurR A Phillips
Sep 1, 1973·The Journal of Experimental Medicine·P G SpearG M Edelman
Apr 26, 1963·Science·N K Jerne, A A Nordin

Related Concepts

Mice, Inbred CBA
Fetal Structures
Immunologic Deficiency Syndromes
Pre-B Lymphocytes
Spleen
Receptors, Antigen, B-Cell
Bone Marrow
Metaphase
Lymph Node Tissue
Cell Differentiation Process

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