The fate of foreign endplates in cross-innervated rat soleus muscle

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
D P KufflerJ K Jansen

Abstract

After transplantation of the superficial fibular and the medial plantar nerve to neighbouring sites in the proximal region of adult rat soleus muscles many muscle fibres were initially innervated by axons in both foreign nerves after resection of the original soleus nerve. The foreign endplates were formed at ectopic sites and were often separately located on individual muscle fibres. After 3-4 weeks many endplates had been eliminated and most muscle fibres were innervated by only a single foreign axon. Many muscle fibres still had multiple esterase-staining endplate sites in the region innervated by the foreign nerve. On examination by electronmicroscopy, some of these sites were seen to have lost their presynaptic terminal while the postsynaptic structure of the endplate remained intact. Other sites were only partially occupied by motor axon terminals. On each muscle fibre there was always at least one fully occupied endplate region. In some instances separate endplate sites on the same muscle fibre were innervated by branches of the same motor axon. We conclude that the elimination of endplates is due to a competitive interaction between motor axons innervating the same muscle fibre. Morphologically, the elimination of funct...Continue Reading

References

Apr 26, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D H HubelS LeVay
Jan 1, 1978·The Journal of Physiology·M J Dennis, J W Yip
Feb 1, 1978·The Journal of Physiology·T Lømo, C R Slater
May 1, 1978·Acta Physiologica Scandinavica·W Thompson
Sep 1, 1977·The Journal of Physiology·J L Rosenthal, P S Taraskevich
Jul 1, 1976·The Journal of Physiology·A R Luff, U Proske
Dec 1, 1976·Journal of Neurocytology·M S LetinskyU J McMahan
Jan 1, 1976·Journal of Neurophysiology·E Frank, J K Jansen
Jun 1, 1966·The Journal of Physiology·S FexJ Zelená
Jul 1, 1973·Experimental Neurology·S Schiaffino, S P Bormioli
Mar 1, 1972·The Journal of Physiology·T Lomo, J Rosenthal
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G S Stent
Jan 18, 1966·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D Barker, M C Ip
Feb 27, 1968·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R Miledi, C R Slater
Sep 1, 1974·The Journal of Physiology·M R Bennett, A G Pettigrew
Aug 1, 1970·The Journal of Physiology·P A Redfern
Dec 20, 1957·The Japanese Journal of Physiology·S IWASAKI

❮ Previous
Next ❯

Citations

Dec 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M J Duxson, P W Sheard
Nov 1, 1982·Journal of Neuroscience Methods·J M Strum, E C Hall-Craggs
Apr 15, 1999·Annual Review of Neuroscience·J R Sanes, J W Lichtman
Jan 1, 1990·Journal of Neurobiology·A A Herrera, M J Werle
Jan 1, 1990·Journal of Neurobiology·D C Van EssenS E Fraser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.