The Fate of L5-S1 With Low-Dose BMP-2 and Pelvic Fixation, With or Without Interbody Fusion, in Adult Deformity Surgery

Spine
Prokopis AnnisBrandon D Lawrence

Abstract

Retrospective comparative case series. Evaluate L5-S1 fusion rates when lower dose of bone morphogenic protein-2 (BMP-2) (average 3.2 mg) and pelvic fixation were used, with or without interbody fusion. Pseudarthrosis at L5-S1 is one of the most common complications of long fusions to the sacrum in adult deformity surgery. Strategies for decreasing pseudarthrosis include interbody fusion, use of BMP-2 at the lumbosacral junction, and the use of sacropelvic fixation, individually or in combination. High-dose BMP-2 (20-40 mg) placed posterolaterally has shown comparable fusion rates with interbody fusion. Retrospective review of 61 consecutive patients with minimum 2-year follow-up at a single institution. All patients had an isolated posterior approach, 5 or more levels fused including L5-S1, use of pelvic fixation, and no prior L5-S1 procedures. The patients were divided in 2 groups for comparison on the basis of the use of an interbody cage/fusion at the L5-S1 level. Revision rates and implant-related complications were also reported. The fusion rate at L5-S1 was 97% (59/61), with no difference between the interbody and no interbody fusion groups (97% vs. 96%, P = 1.0). There were no significant differences in the radiographic...Continue Reading

References

Dec 1, 1992·Journal of Spinal Disorders·L G LenkeP L Schoenecker
Aug 1, 1992·Spine·D H McCordP C McAfee
Oct 1, 1988·Orthopedics·D W GuyerR D Peek
Aug 1, 1993·Spine·R P Jackson, A C McManus
Mar 10, 2001·Journal of Spinal Disorders·G R ButtermannD S Bradford
Nov 20, 2002·Spine·Nathan H LebwohlTheodore A Wagner
Sep 17, 2004·Spine·Charles C EdwardsLawrence G Lenke
Mar 16, 2005·Neurosurgical Focus·Caleb R LippmanDavid W Cahill
Sep 3, 2005·Spine·Scott J LuhmannMario Schootman
Dec 31, 2005·Journal of Neurosurgery. Spine·Alan T VillavicencioJeffrey Thramann
May 12, 2006·Spine·Dhruv B PatederJohn P Kostuik
Oct 6, 2006·Journal of Spinal Disorders & Techniques·John W McClellanNancy Fullmer
Jan 2, 2007·The Spine Journal : Official Journal of the North American Spine Society·Steven D GlassmanJohn R Dimar
Jul 11, 2007·Spine·Steven D GlassmanLeah Y Carreon
Nov 27, 2007·The Spine Journal : Official Journal of the North American Spine Society·David A WongKatherine Wong
Feb 14, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Kyu-Jung ChoJong-Min Lee
Oct 8, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Hans Jörg MeiselUlrich Mansmann
Dec 6, 2008·Journal of Spinal Disorders & Techniques·Rahul VaidyaJoseph G Craig
Jun 2, 2009·The Spine Journal : Official Journal of the North American Spine Society·Jeffrey A RihnTodd J Albert
Jan 30, 2010·Injury·Adam L ShimerAlexander R Vaccaro
Jul 7, 2011·The Spine Journal : Official Journal of the North American Spine Society·Eugene J CarrageeBradley K Weiner
Feb 1, 2012·Orthopaedic Surgery·Christopher K KeplerTodd J Albert
Sep 6, 2013·The Journal of Bone and Joint Surgery. American Volume·Eugene J CarrageeBranko Kopjar
Dec 3, 2013·The Spine Journal : Official Journal of the North American Spine Society·Thomas J ChristensenAlpesh A Patel
Jan 23, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·T FingerP Vajkoczy

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Citations

Apr 15, 2017·Revista Brasileira De Ortopedia·Oberdan Ribeiro Gonçalves de OliveiraMarília Maia Gomes
Jun 9, 2020·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Jeremy SteinbergerHan Jo Kim

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