PMID: 1154802Apr 1, 1975

The fate of metronidazole and tis implications in chemotherapy

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
R M IngsW E Ormerod

Abstract

1. [14C]Metronidazole was rapidly absorbed from the gastro-intestinal tract of rats giving maximum blood levels of radioactivity, equivalent to 6-4 and 6-7 mug metronidazole per ml blood, 1 h after oral dosing. 2. There was rapid equilibration between blood and most tissues, although radioactivity was concentrated in the liver, kidney, gastro-intestinal tract and vaginal secretions. 3. The half-life of clearance of radioactivity from the majority of tissues was between 3 and 4 h, although it was longer in the skin (8 h) and gastro-intestinal tract (14 h). 4. Fourteen radioactive excretion products were detected in rat urine and all the major products were identified. These all contained a nitro group and represented 97 degrees of the total radioactivity excreted in urine. 5. Unchanged metronidazole was secreted throughout the entire length of the gastro-intestinal tract and into the vagina of rats. 6. A hypothesis has been proposed to explain the high clinical efficacy of metronidazole in treating trichomonal and amoebic infections.

References

May 1, 1974·Biochemical Pharmacology·R M IngsW E Ormerod
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Citations

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Sep 1, 1979·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D E SchwartzG Oesterhelt
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Aug 5, 2017·Scientific Reports·Yuanhu PanZonghui Yuan
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Aug 25, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Heidi Cecilie VillmonesØyvind Kommedal

Related Concepts

Autoradiography
Biliary Sludge
Chromatography, Gas-Liquid
Thin Layer Chromatography
Gastrointestinal System
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Feces
Hydroxylation
Intravenous Injections
Intestinal Absorption

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