PMID: 6410593Feb 1, 1983Paper

The fate of N-methyl-N'-(hydroxymethyl)thiourea in the rat

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
A R Jones, P M Mashford

Abstract

1. The fate of N-methyl-N'-(hydroxy[14C]methyl)thiourea (MHT) has been studied in the male Sprague-Dawley rat. The compound is degraded to N-methylthiourea and formaldehyde. 2. N-Methylthiourea is excreted as a urinary metabolite whereas the formaldehyde is not excreted, either in the urine or the expired air, but is metabolized via formate to CO2. 3. At least 50% of an i.p. dose (100 mg/kg) of MHT is excreted unchanged and some of this undergoes hydrolysis within the urine to N-methylthiourea and formaldehyde. Production of formaldehyde leads to the formation of the urinary artefact N-(hydroxymethyl)urea. 4. Tissue-distribution studies with 14C-MHT have shown that radioactivity is selectively associated with the thyroid gland. A preliminary investigation has indicated that MHT has anti-thyroid hormone activity as it lowers the thyroxine in rat serum.

References

Sep 1, 1965·Journal of Clinical Pathology·D Kingston
Feb 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P M Mashford, A R Jones

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Citations

Mar 20, 2008·European Journal of Drug Metabolism and Pharmacokinetics·Bedia Kocyigit-KaymakciogluFeyza Aricioglu
Jan 28, 2004·European Journal of Drug Metabolism and Pharmacokinetics·Bedia Koçyiğit KaymakcioğluFeyza Kartal-Aricioğlu
Jul 1, 1988·Mutation Research·T H Ma, M M Harris

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