PMID: 6500510Nov 1, 1984Paper

The fate of polymeric and secretory immunoglobulin A after retrograde infusion into the common bile duct in rats

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
A L JonesB J Underdown

Abstract

In the rat, plasma IgA is rapidly endocytosed by hepatocytes and translocated to the bile via a receptor-mediated vesicular transport system which appears to remain intact even during cholestasis. During the latter phenomenon, there is an accumulation of secretory IgA (sIgA) in plasma. These data suggest that biliary IgA can be regurgitated into the plasma compartment. The present study was designed to determine the location and mechanism(s) by which this might occur. 125I-labeled human polymeric IgA (pIgA) or sIgA was infused retrograde into the rat common bile duct at a flow rate of 20 microliter per min (5 to 10 micrograms per min pIgA; 7 micrograms per min sIgA) over 1 hr. Blood and liver samples were collected 10, 30 and 60 min, and radioactivity determined. Radioactive label appeared in the blood by 10 min and increased linearly with time. By 30 min, however, the liver had reached saturation. All of the label found in the blood was intact starting material, i.e., pIgA or sIgA. Electron microscopic autoradiography analysis clearly demonstrated the presence of grains in vesicles in hepatocyte pericanalicular cytoplasm, as well as in vesicles near the sinusoidal plasma membrane. No grains were observed associated with bile d...Continue Reading

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Citations

May 1, 1992·Digestive Diseases and Sciences·J Y SungE A Shaffer
Apr 17, 2003·The Journal of Surgical Research·Ulrich BaumgartnerChristian Ihling
Apr 5, 2005·Toxicologic Pathology·Philip F Solter
Jan 1, 1988·Experimental Aging Research·D G Hazzard, J Soban
Apr 1, 1994·The Journal of Cell Biology·G ApodacaK E Mostov
May 1, 1992·Journal of Gastroenterology and Hepatology·V J Desmet
Sep 1, 1989·The Journal of Clinical Investigation·G FrickerP J Meier
Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·D F Keren
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Janet M LarkinVu Tinh
May 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W R Brown, T M Kloppel
Jul 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B StiegerL Landmann
Feb 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I M AriasM St Pierre
Dec 17, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peter L M JansenJan G Hengstler
Feb 1, 1990·Journal of Electron Microscopy Technique·S J Burwen, A L Jones
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heleen C HeystekCees van Kooten

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