The Fate of Residual Tumor Masses That Persist After Stereotactic Body Radiotherapy for Solitary Lung Nodules: Will They Recur?

Clinical Lung Cancer
Ran TakenakaFumiya Baba

Abstract

After stereotactic body radiotherapy (SBRT) to the lung, radiation pneumonitis and fibrotic changes often develop, and the tumor shadow usually becomes indistinguishable from the fibrotic shadow. Occasionally, however, a residual mass in patients with no or mild radiation pneumonitis will be observed on serial computed tomography (CT) scans. The purpose of the present study was to evaluate the fate of such residual masses and, if possible, to determine the types of tumor at increased risk of local recurrence. A total of 50 patients (underlying disease: primary lung cancer in 45, local recurrence in 2, and metastasis in 3) were selected because they had been followed up for > 2 years or until death and had observable CT changes and measurable tumor size for > 1 year, regardless of the influence of radiation pneumonitis. The patients' outcomes were compared according to various patient and tumor characteristics, including the presence and absence of emphysema, tumor size, and tumor shrinkage rate. The median follow-up period was 52 months. Of the 50 patients, only 8 developed local recurrence. The local control rate was 81% at 3 years and 73% at 5 years. The local control rates were similar between patients with a high tumor shri...Continue Reading

References

Jun 1, 1980·Cancer·A R HarwoodV L Fornasier
Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·P RubinJ N Finkelstein
Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·M UematsuS Kusano
Apr 18, 2002·International Journal of Radiation Oncology, Biology, Physics·Yasushi NagataMasahiro Hiraoka
Jun 27, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xueying QiaoRolf Lewensohn
Apr 22, 2004·AJR. American Journal of Roentgenology·Toshiaki TakedaAtsushi Kubo
Sep 1, 2004·International Journal of Radiation Oncology, Biology, Physics·Joern WulfMichael Flentje
Sep 26, 2006·Neurologia Medico-chirurgica·Satoshi UtsukiKiyotaka Fujii
Oct 12, 2007·International Journal of Clinical Oncology·Yukinori MatsuoMasahiro Hiraoka
Sep 5, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pia BaumannRolf Lewensohn
Mar 18, 2010·JAMA : the Journal of the American Medical Association·Robert TimmermanHak Choy
May 19, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shankar SivaDavid Ball
May 31, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Max DaheleSuresh Senan
Jun 7, 2011·International Journal of Radiation Oncology, Biology, Physics·David PalmaSuresh Senan
Feb 7, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kitty HuangDavid A Palma
Feb 26, 2013·Japanese Journal of Clinical Oncology·Hiroshi Onishi, Tsutomu Araki
Jun 4, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pierina NavarriaMarta Scorsetti
Aug 21, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kitty HuangSuresh Senan
Oct 26, 2013·Clinical Lung Cancer·Ajay P SandhuArno J Mundt
Feb 18, 2014·International Journal of Radiation Oncology, Biology, Physics·Kujtim LatifiVladimir Feygelman
Oct 5, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yukinori MatsuoMasahiro Hiraoka
Jan 15, 2015·International Journal of Radiation Oncology, Biology, Physics·Alexander V LouieWilko F A R Verbakel
Feb 11, 2015·Clinical Lung Cancer·Takashi ShintaniMasaki Kokubo
May 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yuta ShibamotoRyuji Asai
Jul 15, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Cinzia FerreroSilvia Novello

❮ Previous
Next ❯

Citations

Jun 2, 2016·The British Journal of Radiology·Sarah A MattonenDavid A Palma
Apr 3, 2019·International Journal of Clinical Oncology·Hiroshi DoiYasumasa Nishimura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved