The fate of the prion protein in the prion/plasminogen complex

Biochemical and Biophysical Research Communications
J A KornblattJeanne Grosclaude

Abstract

The cellular prion protein (PrP(c)) forms complexes with plasminogen. Here, we show that the PrP(c) in this complex is cleaved to yield fragments of PrP(c). The cleavage is accelerated by plasmin but does not appear to be dependent on it.

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Citations

Sep 21, 2004·Nature Reviews. Microbiology·Claudio Soto
May 24, 2012·The Journal of Biological Chemistry·Kwang Soo KimSang Myun Park
Feb 18, 2010·PloS One·José B Oliveira-MartinsAdriano Aguzzi
May 16, 2009·Journal of Virological Methods·Binggong ChangRichard Rubenstein
Sep 27, 2005·Biochemical and Biophysical Research Communications·Heidi TveitMichael A Tranulis
Oct 12, 2012·Prion·Jingjing Liang, Qingzhong Kong
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Aug 21, 2003·The Journal of Biological Chemistry·F Scott HeinemannJuris Ozols
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Jul 11, 2006·Expert Review of Molecular Diagnostics·Marty T LehtoNeil R Cashman
Oct 9, 2004·Wiener klinische Wochenschrift·Herbert Budka
Aug 25, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charles E Mays, Chongsuk Ryou
Feb 15, 2008·Analytical Chemistry·Madhukar VarshneyHarold G Craighead

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