The fate of ultra-low viscosity 14C-hydroxypropyl methylcellulose in rats following gavage administration

Drug and Chemical Toxicology
S J GorzinskiG H Hurst

Abstract

The disposition of 14C-Hydroxypropyl methylcellulose (HPMC) with a viscosity of 2.25 centipoise was studied in male and female Sprague-Dawley rats following a single 500 mg/kg body weight gavage dose, or five consecutive daily doses. Recoveries for the single dose were: feces, greater than 99%; urine, approximately 1%; carcass and tissues, approximately 0.2%; expired air, 0.07%; and bile, 0.05%. Plasma radioactivity had a monophasic excretion half-life of approximately 2 hours for either sex. The majority of the residual radioactivity in the tissues was found in the gastrointestinal tract. The absorbed radioactivity in the urine, based on thin layer chromatography (TLC) analyses, represented methyl ethers of glucose and oligomers; this amounted to 0.56% recovered in a study in which urine samples were isolated from possible contamination by radioactivity in the feces. The 0.56% correlated well with the 0.53% portion of the original dosing solution which consisted of cellulose units with an average molecular weight of less than 1000. Recovery of radioactivity in the feces of rats on the 5-day dosing regimen was 97% and 102% for males and females, respectively, without any evidence for accumulation in tissues. Approximately 1% wa...Continue Reading

References

Dec 1, 1973·Food and Cosmetics Toxicology·S B McCollisterD D McCollister
Mar 1, 1974·Journal of Applied Physiology·P G Harms, S R Ojeda
Nov 1, 1954·Journal of the American Pharmaceutical Association·D D McCOLLISTER, F OYEN
May 1, 1964·Journal of Applied Physiology·J R WEEKS, J D DAVIS

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Citations

Jul 21, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Evan A ThackaberryBarry McIntyre
Nov 17, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura M CoxMartin J Blaser
Aug 29, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·George A Burdock
Nov 9, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Brian P EnrightStephan J Kopytek
Jan 16, 2018·EFSA Journal·UNKNOWN EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)Rudolf Antonius Woutersen
Feb 28, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Soma PatnaikPrashant Kesharwani

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