The fate of XO germ cells in the testes of XO/XY and XO/XY/XYY mouse mosaics: evidence for a spermatogenesis gene on the mouse Y chromosome

Cytogenetics and Cell Genetics
E R Levy, P S Burgoyne

Abstract

A cytogenetic and histological study of nine XO/XY or XO/XY/XYY mosaic mice revealed that XO germ cells were selectively eliminated from the spermatogenic epithelium. Although the XO contribution to the bone marrow in seven mice exceeded 50%, in only two cases were significant numbers of dividing XO spermatogonia present. These XO germ cells only occasionally progressed to meiosis and then degenerated prior to first meiotic metaphase. It was concluded that the mouse Y chromosome carries a "spermatogenesis gene" (or genes) which acts autonomously in the germ cells.

Citations

Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C E Bishop
Mar 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ayako IsotaniMasaru Okabe
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T ZwingmanA Ao
Oct 24, 2012·PloS One·Danielle M MaatoukBlanche Capel
May 2, 2006·Current Opinion in Genetics & Development·Giovanna CamerinoStella Valentini
Dec 1, 1995·Progress in Human Geography·B Moon
Jan 1, 1987·Annals of the New York Academy of Sciences·B M Cattanach
Sep 23, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D J Elliott, H J Cooke
Mar 21, 2001·Nature Reviews. Genetics·B T LahnK Jegalian
Dec 1, 1988·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A McLaren
May 17, 2017·Science Advances·Arata HondaChihiro Koshimoto
Nov 30, 2000·Journal of Endocrinological Investigation·N A Affara, M J Mitchell
Jan 1, 1992·Andrologia·P S BurgoyneS K Mahadevaiah

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.