The fault is not in her parents but in her insula--a neurobiological hypothesis of anorexia nervosa

European Eating Disorders Review : the Journal of the Eating Disorders Association
Ken NunnB Lask

Abstract

The reported abnormalities of brain function in anorexia nervosa (AN) include impairment of neural circuits involving cortical (orbito-frontal, somatosensory and parietal) and sub-cortical (amygdala, hippocampus, thalamus, hypothalamus and striatum) structures. The insular cortex serves an integrative function for all the structures relevant to the features of AN and as such may be central to this impairment. We hypothesise that a rate limiting dysfunction of neural circuitry integrated by the insula can account for the clinical phenomena of AN. Such dysfunction could account for the known psychopathology, neuroimaging abnormalities and neuropsychological deficits. Proposals to test this hypothesis are made.

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Citations

Oct 30, 2012·Der Nervenarzt·K-J Bär
Jun 5, 2012·Current Psychiatry Reports·Amelia Kidd, Joanna Steinglass
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