The feared five fungal infections in kidney transplant recipients: A single-center 20-year experience

Clinical Transplantation
Sandesh ParajuliDidier A Mandelbrot

Abstract

Invasive fungal infections are a feared complication in kidney transplant recipients (KTRs). Here we present the University of Wisconsin experience with 5 invasive fungal infections-aspergillosis, cryptococcosis, histoplasmosis, blastomycosis, and coccidioidomycosis-in KTRs transplanted between 01/01/1994 and 06/30/2014. During this period, there were 128 cases of fungal infections; aspergillosis was the most common (72), followed by cryptococcosis (29), histoplasmosis (14), blastomycosis (10), and coccidioidomycosis (3). The mean interval from transplant to fungal infection was 3.19 ± 3.58 years (range 5 days-15.8 years). By 6 months postinfection, there were 53 (41%) graft failures and 24 (19%) deaths. Graft failure occurred in 46%, 38%, 21%, 40%, and 67% of patients with aspergillosis, cryptococcosis, histoplasmosis, blastomycosis, and coccidioidomycosis, respectively. Anti-thymocyte globulin (ATG) induction (HR, 1.49; 95% CI, 1.03-2.16; P = .04), diabetes (HR, 1.53; 95% CI, 1.05-2.21; P = .03), and age (HR, 1.47; 95% CI, 1.27-1.70; P ≤ .001) were associated with an increased risk for infection in univariate analysis. Multivariate adjustment retained ATG induction and older age. A large proportion of kidney transplant recipi...Continue Reading

References

Nov 11, 1992·The American Journal of Medicine·W E DismukesC Bowles-Patton
Mar 7, 1974·The New England Journal of Medicine·G A SarosiR S Kronenberg
Mar 1, 1982·Archives of Internal Medicine·I M CohenD A Ogden
Jan 1, 1997·Clinical Microbiology Reviews·R Patel, C V Paya
Oct 31, 1997·American Journal of Infection Control·N Singh
Apr 9, 1999·Medicine·D L Paterson, N Singh
Mar 23, 2000·Respirology : Official Journal of the Asian Pacific Society of Respirology·J M ChaY Koh
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N Singh
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D R Snydman
Oct 6, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J E Blair, J L Logan
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S AsciogluUNKNOWN Mycoses Study Group of the National Institute of Allergy and Infectious Diseases
Jan 30, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J A Maertens
Apr 15, 2005·Journal of the American Society of Nephrology : JASN·Camille N Kotton, Jay A Fishman
Jun 7, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J GavaldaUNKNOWN RESITRA (Spanish Network for Research on Infection in Transplantation)
Apr 13, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·G M GauthierD R Andes
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ben De PauwUNKNOWN National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Jul 30, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J A DavisJ A Fishman
Feb 2, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D NeofytosK A Marr
Mar 12, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasTom M Chiller
Apr 9, 2010·Current Opinion in Pulmonary Medicine·Rami Sherif, Brahm H Segal
Jun 1, 2009·Expert Review of Hematology·Jane A Cecil, Richard P Wenzel
Jan 6, 2011·Indian Journal of Nephrology·V Jha
Jul 14, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S A GrimN M Clark
Aug 31, 2011·F1000 Medicine Reports·Chian-Yong Low, Coleman Rotstein
Sep 6, 2011·Emerging Infectious Diseases·John W BaddleyJeffrey R Curtis
Oct 18, 2011·Emerging Infectious Diseases·Benjamin J ParkDimitrios P Kontoyiannis
Jun 2, 2012·TheScientificWorldJournal·Jovana CukuranovicVladisav Stefanovic
Sep 15, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Shamila Karuthu, Emily A Blumberg
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R MillerUNKNOWN AST Infectious Diseases Community of Practice
Sep 21, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maha AssiDaniel R Kaul
Mar 5, 2014·Transplant Infectious Disease : an Official Journal of the Transplantation Society·C A KauffmanP G Pappas
Jun 1, 2013·Therapeutic Advances in Infectious Disease·Jose A VazquezGeorge Alangaden
Feb 15, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Line HeylenBen Sprangers
Oct 16, 2016·Advances in Chronic Kidney Disease·Sandesh ParajuliArjang Djamali

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Citations

Jul 13, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Taksaon AngsutararuxWalaiporn Wangchinda
Aug 12, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·María Asunción Pérez-Jacoiste AsínJosé María Aguado
Apr 22, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Akansha AgrawalLara Danziger-Isakov
Jun 18, 2021·Respiratory Medicine·D WilmesN Kanaan

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Related Concepts

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Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

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